Liu Y - Search Results

1

5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2.

Wei M, Zhou Y, Li C, Yang Y, Liu T, Liu Y, Wei Y, Liu N, Liu S, Wang Q, Cao S, Sun Y, Sheng P, Lu C, Yang C, Liu X, Yang G. Wei M, et al. Among authors: liu y, liu x, liu n, liu s, liu t. J Med Chem. 2021 Sep 9;64(17):12537-12547. doi: 10.1021/acs.jmedchem.1c00267. Epub 2021 Aug 5. J Med Chem. 2021. PMID: 34351142

2

First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo.

Wei M, Zhao R, Cao Y, Wei Y, Li M, Dong Z, Liu Y, Ruan H, Li Y, Cao S, Tang Z, Zhou Y, Song W, Wang Y, Wang J, Yang G, Yang C. Wei M, et al. Among authors: liu y. Eur J Med Chem. 2021 Jan 1;209:112903. doi: 10.1016/j.ejmech.2020.112903. Epub 2020 Oct 9. Eur J Med Chem. 2021. PMID: 33256948

3

Discovery and Optimization of a Novel 2H-Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor.

Wei Y, Tang Y, Zhou Y, Yang Y, Cui Y, Wang X, Wang Y, Liu Y, Liu N, Wang Q, Li C, Ruan H, Zhou H, Wei M, Yang G, Yang C. Wei Y, et al. Among authors: liu y, liu n. J Med Chem. 2021 Jul 8;64(13):9078-9099. doi: 10.1021/acs.jmedchem.1c00174. Epub 2021 Jun 15. J Med Chem. 2021. PMID: 34129329

4

Development of Alectinib-Based PROTACs as Novel Potent Degraders of Anaplastic Lymphoma Kinase (ALK).

Xie S, Sun Y, Liu Y, Li X, Li X, Zhong W, Zhan F, Zhu J, Yao H, Yang DH, Chen ZS, Xu J, Xu S. Xie S, et al. Among authors: liu y. J Med Chem. 2021 Jul 8;64(13):9120-9140. doi: 10.1021/acs.jmedchem.1c00270. Epub 2021 Jun 28. J Med Chem. 2021. PMID: 34176264

5

Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells.

Cao S, Ma L, Liu Y, Wei M, Yao Y, Li C, Wang R, Liu N, Dong Z, Li X, Li M, Wang X, Yang C, Yang G. Cao S, et al. Among authors: liu y, liu n. J Med Chem. 2021 Nov 25;64(22):16497-16511. doi: 10.1021/acs.jmedchem.1c00996. Epub 2021 Oct 25. J Med Chem. 2021. PMID: 34694800

6

Novel inhibitors of AChE and Aβ aggregation with neuroprotective properties as lead compounds for the treatment of Alzheimer's disease.

Liu Y, Uras G, Onuwaje I, Li W, Yao H, Xu S, Li X, Li X, Phillips J, Allen S, Gong Q, Zhang H, Zhu Z, Liu J, Xu J. Liu Y, et al. Among authors: liu j. Eur J Med Chem. 2022 May 5;235:114305. doi: 10.1016/j.ejmech.2022.114305. Epub 2022 Mar 18. Eur J Med Chem. 2022. PMID: 35339839

7

Discovery of novel and bioavailable histone deacetylases and cyclin-dependent kinases dual inhibitor to impair the stemness of leukemia cells.

Liu Y, Wei Y, Wang X, Ma L, Li X, Sun Y, Wu Y, Zhang L, Wang J, Li M, Zhang K, Wei M, Yang G, Yang C. Liu Y, et al. Eur J Med Chem. 2023 Mar 5;249:115140. doi: 10.1016/j.ejmech.2023.115140. Epub 2023 Jan 21. Eur J Med Chem. 2023. PMID: 36736154

8

Design, synthesis and evaluation of a pyrazolo[3,4-d]pyrimidine derivative as a novel and potent TGFβ1R1 inhibitor.

Wang Y, Liu Y, Zhang Y, Zhang Z, Xu L, Wang J, Yang Y, Hu B, Yao Y, Wei M, Wang J, Tang B, Zhang K, Liu S, Yang G. Wang Y, et al. Among authors: liu y, liu s. Eur J Med Chem. 2024 May 5;271:116395. doi: 10.1016/j.ejmech.2024.116395. Epub 2024 Apr 12. Eur J Med Chem. 2024. PMID: 38626523

9

Neratinib impairs function of m6A recognition on AML1-ETO pre-mRNA and induces differentiation of t (8;21) AML cells by targeting HNRNPA3.

Liu Y, Zheng L, Li Y, Ma L, Zheng N, Liu X, Zhao Y, Yu L, Liu N, Liu S, Zhang K, Zhou J, Wei M, Yang C, Yang G. Liu Y, et al. Among authors: liu x, liu n, liu s. Cancer Lett. 2024 Jul 10;594:216980. doi: 10.1016/j.canlet.2024.216980. Epub 2024 May 24. Cancer Lett. 2024. PMID: 38797229

10

Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates.

Wu H, Li X, He C, Liu Y, Wang C, Yang X, Ma F, Liu J, Xu J. Wu H, et al. Among authors: liu j, liu y. Bioorg Med Chem. 2022 Jun 15;64:116776. doi: 10.1016/j.bmc.2022.116776. Epub 2022 Apr 25. Bioorg Med Chem. 2022. PMID: 35483137

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