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Page 1
Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system.
Bolaender A, Zatorska D, He H, Joshi S, Sharma S, Digwal CS, Patel HJ, Sun W, Imber BS, Ochiana SO, Patel MR, Shrestha L, Shah SK, Wang S, Karimov R, Tao H, Patel PD, Martin AR, Yan P, Panchal P, Almodovar J, Corben A, Rimner A, Ginsberg SD, Lyashchenko S, Burnazi E, Ku A, Kalidindi T, Lee SG, Grkovski M, Beattie BJ, Zanzonico P, Lewis JS, Larson S, Rodina A, Pillarsetty N, Tabar V, Dunphy MP, Taldone T, Shimizu F, Chiosis G. Bolaender A, et al. Among authors: patel mr, patel pd, patel hj. Nat Commun. 2021 Aug 3;12(1):4669. doi: 10.1038/s41467-021-24821-2. Nat Commun. 2021. PMID: 34344873 Free PMC article.
Selective targeting of the stress chaperome as a therapeutic strategy.
Taldone T, Ochiana SO, Patel PD, Chiosis G. Taldone T, et al. Among authors: patel pd. Trends Pharmacol Sci. 2014 Nov;35(11):592-603. doi: 10.1016/j.tips.2014.09.001. Epub 2014 Sep 25. Trends Pharmacol Sci. 2014. PMID: 25262919 Free PMC article. Review.
Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2.
Patel PD, Yan P, Seidler PM, Patel HJ, Sun W, Yang C, Que NS, Taldone T, Finotti P, Stephani RA, Gewirth DT, Chiosis G. Patel PD, et al. Among authors: patel hj. Nat Chem Biol. 2013 Nov;9(11):677-84. doi: 10.1038/nchembio.1335. Epub 2013 Sep 1. Nat Chem Biol. 2013. PMID: 23995768 Free PMC article.
Identification of an allosteric pocket on human hsp70 reveals a mode of inhibition of this therapeutically important protein.
Rodina A, Patel PD, Kang Y, Patel Y, Baaklini I, Wong MJ, Taldone T, Yan P, Yang C, Maharaj R, Gozman A, Patel MR, Patel HJ, Chirico W, Erdjument-Bromage H, Talele TT, Young JC, Chiosis G. Rodina A, et al. Among authors: patel y, patel mr, patel pd, patel hj. Chem Biol. 2013 Dec 19;20(12):1469-80. doi: 10.1016/j.chembiol.2013.10.008. Epub 2013 Nov 14. Chem Biol. 2013. PMID: 24239008 Free PMC article.
Heat shock protein 70 inhibitors. 1. 2,5'-thiodipyrimidine and 5-(phenylthio)pyrimidine acrylamides as irreversible binders to an allosteric site on heat shock protein 70.
Kang Y, Taldone T, Patel HJ, Patel PD, Rodina A, Gozman A, Maharaj R, Clement CC, Patel MR, Brodsky JL, Young JC, Chiosis G. Kang Y, et al. Among authors: patel mr, patel pd, patel hj. J Med Chem. 2014 Feb 27;57(4):1188-207. doi: 10.1021/jm401551n. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24548207 Free PMC article.
Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70.
Taldone T, Kang Y, Patel HJ, Patel MR, Patel PD, Rodina A, Patel Y, Gozman A, Maharaj R, Clement CC, Lu A, Young JC, Chiosis G. Taldone T, et al. Among authors: patel y, patel mr, patel pd, patel hj. J Med Chem. 2014 Feb 27;57(4):1208-24. doi: 10.1021/jm401552y. Epub 2014 Feb 18. J Med Chem. 2014. PMID: 24548239 Free PMC article.
Affinity purification probes of potential use to investigate the endogenous Hsp70 interactome in cancer.
Rodina A, Taldone T, Kang Y, Patel PD, Koren J 3rd, Yan P, DaGama Gomes EM, Yang C, Patel MR, Shrestha L, Ochiana SO, Santarossa C, Maharaj R, Gozman A, Cox MB, Erdjument-Bromage H, Hendrickson RC, Cerchietti L, Melnick A, Guzman ML, Chiosis G. Rodina A, et al. Among authors: patel mr, patel pd. ACS Chem Biol. 2014 Aug 15;9(8):1698-705. doi: 10.1021/cb500256u. Epub 2014 Jun 17. ACS Chem Biol. 2014. PMID: 24934503 Free PMC article.
Design, synthesis, and evaluation of small molecule Hsp90 probes.
Taldone T, Zatorska D, Patel PD, Zong H, Rodina A, Ahn JH, Moulick K, Guzman ML, Chiosis G. Taldone T, et al. Among authors: patel pd. Bioorg Med Chem. 2011 Apr 15;19(8):2603-14. doi: 10.1016/j.bmc.2011.03.013. Epub 2011 Mar 12. Bioorg Med Chem. 2011. PMID: 21459002 Free PMC article. Review.
284 results