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Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease.
Wright MB, Varona Santos J, Kemmer C, Maugeais C, Carralot JP, Roever S, Molina J, Ducasa GM, Mitrofanova A, Sloan A, Ahmad A, Pedigo C, Ge M, Pressly J, Barisoni L, Mendez A, Sgrignani J, Cavalli A, Merscher S, Prunotto M, Fornoni A. Wright MB, et al. Nat Commun. 2021 Aug 2;12(1):4662. doi: 10.1038/s41467-021-24890-3. Nat Commun. 2021. PMID: 34341345 Free PMC article.
Discovery of tetrahydro-cyclopenta[b]indole as selective LXRs modulator.
Ratni H, Blum-Kaelin D, Dehmlow H, Hartman P, Jablonski P, Masciadri R, Maugeais C, Patiny-Adam A, Panday N, Wright M. Ratni H, et al. Bioorg Med Chem Lett. 2009 Mar 15;19(6):1654-7. doi: 10.1016/j.bmcl.2009.01.109. Epub 2009 Feb 6. Bioorg Med Chem Lett. 2009. PMID: 19231176
6-Alkoxy-5-aryl-3-pyridinecarboxamides, a new series of bioavailable cannabinoid receptor type 1 (CB1) antagonists including peripherally selective compounds.
Röver S, Andjelkovic M, Bénardeau A, Chaput E, Guba W, Hebeisen P, Mohr S, Nettekoven M, Obst U, Richter WF, Ullmer C, Waldmeier P, Wright MB. Röver S, et al. Among authors: wright mb. J Med Chem. 2013 Dec 27;56(24):9874-96. doi: 10.1021/jm4010708. Epub 2013 Nov 20. J Med Chem. 2013. PMID: 24175572
New Insights on the mechanism of PPAR-targeted drugs.
Grether U, Klaus W, Kuhn B, Maerki HP, Mohr P, Wright MB. Grether U, et al. Among authors: wright mb. ChemMedChem. 2010 Dec 3;5(12):1973-6. doi: 10.1002/cmdc.201000446. ChemMedChem. 2010. PMID: 21069658 No abstract available.
52 results