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Page 1
Structure-activity relationships of actively FhuE transported rifabutin derivatives with potent activity against Acinetobacter baumannii.
Maingot M, Bourotte M, Vetter AC, Schellhorn B, Antraygues K, Scherer H, Gitzinger M, Kemmer C, Dale GE, Defert O, Lociuro S, Brönstrup M, Willand N, Trebosc V. Maingot M, et al. Among authors: kemmer c. Eur J Med Chem. 2023 Apr 5;252:115257. doi: 10.1016/j.ejmech.2023.115257. Epub 2023 Mar 16. Eur J Med Chem. 2023. PMID: 36948128
Targeting virulence regulation to disarm Acinetobacter baumannii pathogenesis.
Trebosc V, Lucchini V, Narwal M, Wicki B, Gartenmann S, Schellhorn B, Schill J, Bourotte M, Frey D, Grünberg J, Trauner A, Ferrari L, Felici A, Champion OL, Gitzinger M, Lociuro S, Kammerer RA, Kemmer C, Pieren M. Trebosc V, et al. Among authors: kemmer c. Virulence. 2022 Dec;13(1):1868-1883. doi: 10.1080/21505594.2022.2135273. Virulence. 2022. PMID: 36261919 Free PMC article.
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Flipo M, Frita R, Bourotte M, Martínez-Martínez MS, Boesche M, Boyle GW, Derimanov G, Drewes G, Gamallo P, Ghidelli-Disse S, Gresham S, Jiménez E, de Mercado J, Pérez-Herrán E, Porras-De Francisco E, Rullas J, Casado P, Leroux F, Piveteau C, Kiass M, Mathys V, Soetaert K, Megalizzi V, Tanina A, Wintjens R, Antoine R, Brodin P, Delorme V, Moune M, Djaout K, Slupek S, Kemmer C, Gitzinger M, Ballell L, Mendoza-Losana A, Lociuro S, Deprez B, Barros-Aguirre D, Remuiñán MJ, Willand N, Baulard AR. Flipo M, et al. Among authors: kemmer c. Sci Transl Med. 2022 May 4;14(643):eaaz6280. doi: 10.1126/scitranslmed.aaz6280. Epub 2022 May 4. Sci Transl Med. 2022. PMID: 35507672
Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease.
Wright MB, Varona Santos J, Kemmer C, Maugeais C, Carralot JP, Roever S, Molina J, Ducasa GM, Mitrofanova A, Sloan A, Ahmad A, Pedigo C, Ge M, Pressly J, Barisoni L, Mendez A, Sgrignani J, Cavalli A, Merscher S, Prunotto M, Fornoni A. Wright MB, et al. Among authors: kemmer c. Nat Commun. 2021 Aug 2;12(1):4662. doi: 10.1038/s41467-021-24890-3. Nat Commun. 2021. PMID: 34341345 Free PMC article.
In vitro activity of rifabutin against 293 contemporary carbapenem-resistant Acinetobacter baumannii clinical isolates and characterization of rifabutin mode of action and resistance mechanisms.
Trebosc V, Schellhorn B, Schill J, Lucchini V, Bühler J, Bourotte M, Butcher JJ, Gitzinger M, Lociuro S, Kemmer C, Dale GE. Trebosc V, et al. Among authors: kemmer c. J Antimicrob Chemother. 2020 Dec 1;75(12):3552-3562. doi: 10.1093/jac/dkaa370. J Antimicrob Chemother. 2020. PMID: 32869081 Free PMC article.
A nutrient-limited screen unmasks rifabutin hyperactivity for extensively drug-resistant Acinetobacter baumannii.
Luna B, Trebosc V, Lee B, Bakowski M, Ulhaq A, Yan J, Lu P, Cheng J, Nielsen T, Lim J, Ketphan W, Eoh H, McNamara C, Skandalis N, She R, Kemmer C, Lociuro S, Dale GE, Spellberg B. Luna B, et al. Among authors: kemmer c. Nat Microbiol. 2020 Sep;5(9):1134-1143. doi: 10.1038/s41564-020-0737-6. Epub 2020 Jun 8. Nat Microbiol. 2020. PMID: 32514072 Free PMC article.
113 results