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Intranasal insulin rescues repeated anesthesia-induced deficits in synaptic plasticity and memory and prevents apoptosis in neonatal mice via mTORC1.
Roque PS, Hooshmandi M, Neagu-Lund L, Yin S, Yousefpour N, Sato H, Sato T, Nakadate Y, Kawakami A, Tahmasebi S, Ribeiro-da-Silva A, Gkogkas CG, Prager-Khoutorsky M, Schricker T, Wykes L, Khoutorsky A. Roque PS, et al. Sci Rep. 2021 Jul 29;11(1):15490. doi: 10.1038/s41598-021-94849-3. Sci Rep. 2021. PMID: 34326413 Free PMC article.
Translational control of nociception via 4E-binding protein 1.
Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, Sonenberg N. Khoutorsky A, et al. Elife. 2015 Dec 18;4:e12002. doi: 10.7554/eLife.12002. Elife. 2015. PMID: 26678009 Free PMC article.
eIF2α phosphorylation controls thermal nociception.
Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, Sonenberg N. Khoutorsky A, et al. Proc Natl Acad Sci U S A. 2016 Oct 18;113(42):11949-11954. doi: 10.1073/pnas.1614047113. Epub 2016 Oct 3. Proc Natl Acad Sci U S A. 2016. PMID: 27698114 Free PMC article.
Epiregulin and EGFR interactions are involved in pain processing.
Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Cole T, Khuong TM, Mir E, Gibson DG, Wieskopf JS, Sotocinal SG, Austin JS, Meloto CB, Gitt JH, Gkogkas C, Sonenberg N, Greenspan JD, Fillingim RB, Ohrbach R, Slade GD, Knott C, Dubner R, Nackley AG, Ribeiro-da-Silva A, Neely GG, Maixner W, Zaykin DV, Mogil JS, Diatchenko L. Martin LJ, et al. J Clin Invest. 2017 Sep 1;127(9):3353-3366. doi: 10.1172/JCI87406. Epub 2017 Aug 7. J Clin Invest. 2017. PMID: 28783046 Free PMC article.
Single-cell RNA sequencing reveals time- and sex-specific responses of mouse spinal cord microglia to peripheral nerve injury and links ApoE to chronic pain.
Tansley S, Uttam S, Ureña Guzmán A, Yaqubi M, Pacis A, Parisien M, Deamond H, Wong C, Rabau O, Brown N, Haglund L, Ouellet J, Santaguida C, Ribeiro-da-Silva A, Tahmasebi S, Prager-Khoutorsky M, Ragoussis J, Zhang J, Salter MW, Diatchenko L, Healy LM, Mogil JS, Khoutorsky A. Tansley S, et al. Nat Commun. 2022 Feb 11;13(1):843. doi: 10.1038/s41467-022-28473-8. Nat Commun. 2022. PMID: 35149686 Free PMC article.
mTORC2 mediates structural plasticity in distal nociceptive endings that contributes to pain hypersensitivity following inflammation.
Wong C, Barkai O, Wang F, Perez CT, Lev S, Cai W, Tansley S, Yousefpour N, Hooshmandi M, Lister KC, Latif M, Cuello AC, Prager-Khoutorsky M, Mogil JS, Séguéla P, De Koninck Y, Ribeiro-da-Silva A, Binshtok AM, Khoutorsky A. Wong C, et al. J Clin Invest. 2022 Aug 1;132(15):e152635. doi: 10.1172/JCI152635. J Clin Invest. 2022. PMID: 35579957 Free PMC article.
167 results