Spry C - Search Results

1

A novel heteromeric pantothenate kinase complex in apicomplexan parasites.

Tjhin ET, Howieson VM, Spry C, van Dooren GG, Saliba KJ. Tjhin ET, et al. Among authors: spry c. PLoS Pathog. 2021 Jul 29;17(7):e1009797. doi: 10.1371/journal.ppat.1009797. eCollection 2021 Jul. PLoS Pathog. 2021. PMID: 34324601 Free PMC article.

2

A class of pantothenic acid analogs inhibits Plasmodium falciparum pantothenate kinase and represses the proliferation of malaria parasites.

Spry C, Chai CL, Kirk K, Saliba KJ. Spry C, et al. Antimicrob Agents Chemother. 2005 Nov;49(11):4649-57. doi: 10.1128/AAC.49.11.4649-4657.2005. Antimicrob Agents Chemother. 2005. PMID: 16251308 Free PMC article.

3

Feedback inhibition of pantothenate kinase regulates pantothenol uptake by the malaria parasite.

Lehane AM, Marchetti RV, Spry C, van Schalkwyk DA, Teng R, Kirk K, Saliba KJ. Lehane AM, et al. Among authors: spry c. J Biol Chem. 2007 Aug 31;282(35):25395-405. doi: 10.1074/jbc.M704610200. Epub 2007 Jun 20. J Biol Chem. 2007. PMID: 17581817 Free article.

4

Coenzyme A biosynthesis: an antimicrobial drug target.

Spry C, Kirk K, Saliba KJ. Spry C, et al. FEMS Microbiol Rev. 2008 Jan;32(1):56-106. doi: 10.1111/j.1574-6976.2007.00093.x. FEMS Microbiol Rev. 2008. PMID: 18173393 Free article. Review.

5

The human malaria parasite Plasmodium falciparum is not dependent on host coenzyme A biosynthesis.

Spry C, Saliba KJ. Spry C, et al. J Biol Chem. 2009 Sep 11;284(37):24904-13. doi: 10.1074/jbc.M109.025312. Epub 2009 Jul 7. J Biol Chem. 2009. PMID: 19584050 Free PMC article.

6

Pantothenate utilization by Plasmodium as a target for antimalarial chemotherapy.

Spry C, van Schalkwyk DA, Strauss E, Saliba KJ. Spry C, et al. Infect Disord Drug Targets. 2010 Jun;10(3):200-16. doi: 10.2174/187152610791163390. Infect Disord Drug Targets. 2010. PMID: 20334619 Review.

7

Pantothenamides are potent, on-target inhibitors of Plasmodium falciparum growth when serum pantetheinase is inactivated.

Spry C, Macuamule C, Lin Z, Virga KG, Lee RE, Strauss E, Saliba KJ. Spry C, et al. PLoS One. 2013;8(2):e54974. doi: 10.1371/journal.pone.0054974. Epub 2013 Feb 6. PLoS One. 2013. PMID: 23405100 Free PMC article.

8

A miniaturized assay for measuring small molecule phosphorylation in the presence of complex matrices.

Spry C, Saliba KJ, Strauss E. Spry C, et al. Anal Biochem. 2014 Apr 15;451:76-8. doi: 10.1016/j.ab.2013.12.010. Epub 2013 Dec 12. Anal Biochem. 2014. PMID: 24333332

9

Structural modification of pantothenamides counteracts degradation by pantetheinase and improves antiplasmodial activity.

de Villiers M, Macuamule C, Spry C, Hyun YM, Strauss E, Saliba KJ. de Villiers M, et al. Among authors: spry c. ACS Med Chem Lett. 2013 Jun 17;4(8):784-9. doi: 10.1021/ml400180d. eCollection 2013 Aug 8. ACS Med Chem Lett. 2013. PMID: 24900746 Free PMC article.

10

Exploiting the coenzyme A biosynthesis pathway for the identification of new antimalarial agents: the case for pantothenamides.

Saliba KJ, Spry C. Saliba KJ, et al. Among authors: spry c. Biochem Soc Trans. 2014 Aug;42(4):1087-93. doi: 10.1042/BST20140158. Biochem Soc Trans. 2014. PMID: 25110007 Review.

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