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Page 1
Inhibition of NAE-dependent protein hyper-NEDDylation in cystic cholangiocytes halts cystogenesis in experimental models of polycystic liver disease.
Lee-Law PY, Olaizola P, Caballero-Camino FJ, Izquierdo-Sanchez L, Rodrigues PM, Perugorria MJ, Azkargorta M, Elortza F, Martinez-Chantar ML, Aspichueta P, Marzioni M, Bujanda L, Drenth JPH, Banales JM. Lee-Law PY, et al. United European Gastroenterol J. 2021 Sep;9(7):848-859. doi: 10.1002/ueg2.12126. Epub 2021 Jul 26. United European Gastroenterol J. 2021. PMID: 34310849 Free PMC article.
Mitochondrial antiviral signaling protein enhances MASLD progression through the ERK/TNFα/NFκβ pathway.
Nóvoa E, da Silva Lima N, Gonzalez-Rellan MJ, Chantada-Vazquez MDP, Verheij J, Rodriguez A, Esquinas-Roman EM, Fondevila MF, Koning M, Fernandez U, Cabaleiro A, Parracho T, Iglesias-Moure J, Seoane S, Porteiro B, Escudero A, Senra A, Perez-Fernandez R, López M, Fidalgo M, Guallar D, Martinez-Chantar ML, Dieguez C, Varela-Rey M, Prevot V, Schwaninger M, Meijnikman A, Bravo SB, Frühbeck G, Nogueiras R. Nóvoa E, et al. Hepatology. 2024 May 19. doi: 10.1097/HEP.0000000000000930. Online ahead of print. Hepatology. 2024. PMID: 38761407
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase.
Martínez-Chantar ML, Vázquez-Chantada M, Garnacho M, Latasa MU, Varela-Rey M, Dotor J, Santamaria M, Martínez-Cruz LA, Parada LA, Lu SC, Mato JM. Martínez-Chantar ML, et al. Gastroenterology. 2006 Jul;131(1):223-32. doi: 10.1053/j.gastro.2006.04.019. Gastroenterology. 2006. PMID: 16831604
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML. Martínez-López N, et al. Gastroenterology. 2012 Sep;143(3):787-798.e13. doi: 10.1053/j.gastro.2012.05.050. Epub 2012 Jun 8. Gastroenterology. 2012. PMID: 22687285 Free PMC article.
Stabilization of LKB1 and Akt by neddylation regulates energy metabolism in liver cancer.
Barbier-Torres L, Delgado TC, García-Rodríguez JL, Zubiete-Franco I, Fernández-Ramos D, Buqué X, Cano A, Gutiérrez-de Juan V, Fernández-Domínguez I, Lopitz-Otsoa F, Fernández-Tussy P, Boix L, Bruix J, Villa E, Castro A, Lu SC, Aspichueta P, Xirodimas D, Varela-Rey M, Mato JM, Beraza N, Martínez-Chantar ML. Barbier-Torres L, et al. Oncotarget. 2015 Feb 10;6(4):2509-23. doi: 10.18632/oncotarget.3191. Oncotarget. 2015. PMID: 25650664 Free PMC article.
Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves.
Gomez-Sanchez JA, Carty L, Iruarrizaga-Lejarreta M, Palomo-Irigoyen M, Varela-Rey M, Griffith M, Hantke J, Macias-Camara N, Azkargorta M, Aurrekoetxea I, De Juan VG, Jefferies HB, Aspichueta P, Elortza F, Aransay AM, Martínez-Chantar ML, Baas F, Mato JM, Mirsky R, Woodhoo A, Jessen KR. Gomez-Sanchez JA, et al. J Cell Biol. 2015 Jul 6;210(1):153-68. doi: 10.1083/jcb.201503019. J Cell Biol. 2015. PMID: 26150392 Free PMC article.
Deregulated neddylation in liver fibrosis.
Zubiete-Franco I, Fernández-Tussy P, Barbier-Torres L, Simon J, Fernández-Ramos D, Lopitz-Otsoa F, Gutiérrez-de Juan V, de Davalillo SL, Duce AM, Iruzubieta P, Taibo D, Crespo J, Caballeria J, Villa E, Aurrekoetxea I, Aspichueta P, Varela-Rey M, Lu SC, Mato JM, Beraza N, Delgado TC, Martínez-Chantar ML. Zubiete-Franco I, et al. Hepatology. 2017 Feb;65(2):694-709. doi: 10.1002/hep.28933. Epub 2016 Dec 30. Hepatology. 2017. PMID: 28035772 Free PMC article.
Hepatic p63 regulates steatosis via IKKβ/ER stress.
Porteiro B, Fondevila MF, Delgado TC, Iglesias C, Imbernon M, Iruzubieta P, Crespo J, Zabala-Letona A, Fernø J, González-Terán B, Matesanz N, Hernández-Cosido L, Marcos M, Tovar S, Vidal A, Sánchez-Ceinos J, Malagon MM, Pombo C, Zalvide J, Carracedo A, Buque X, Dieguez C, Sabio G, López M, Aspichueta P, Martínez-Chantar ML, Nogueiras R. Porteiro B, et al. Nat Commun. 2017 May 8;8:15111. doi: 10.1038/ncomms15111. Nat Commun. 2017. PMID: 28480888 Free PMC article.
225 results