Cookson MR - Search Results

1

LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.

Emmenegger M, De Cecco E, Hruska-Plochan M, Eninger T, Schneider MM, Barth M, Tantardini E, de Rossi P, Bacioglu M, Langston RG, Kaganovich A, Bengoa-Vergniory N, Gonzalez-Guerra A, Avar M, Heinzer D, Reimann R, Häsler LM, Herling TW, Matharu NS, Landeck N, Luk K, Melki R, Kahle PJ, Hornemann S, Knowles TPJ, Cookson MR, Polymenidou M, Jucker M, Aguzzi A. Emmenegger M, et al. Among authors: cookson mr. EMBO Mol Med. 2021 Sep 7;13(9):e14745. doi: 10.15252/emmm.202114745. Epub 2021 Jul 26. EMBO Mol Med. 2021. PMID: 34309222 Free PMC article.

2

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.

Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, Ahmad R, Miller DW, Kesavapany S, Singleton A, Lees A, Harvey RJ, Harvey K, Cookson MR. Greggio E, et al. Among authors: cookson mr. Neurobiol Dis. 2006 Aug;23(2):329-41. doi: 10.1016/j.nbd.2006.04.001. Epub 2006 Jun 5. Neurobiol Dis. 2006. PMID: 16750377

3

Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1.

Greggio E, Lewis PA, van der Brug MP, Ahmad R, Kaganovich A, Ding J, Beilina A, Baker AK, Cookson MR. Greggio E, et al. Among authors: cookson mr. J Neurochem. 2007 Jul;102(1):93-102. doi: 10.1111/j.1471-4159.2007.04523.x. Epub 2007 Mar 29. J Neurochem. 2007. PMID: 17394548 Free article.

4

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation.

Greggio E, Zambrano I, Kaganovich A, Beilina A, Taymans JM, Daniëls V, Lewis P, Jain S, Ding J, Syed A, Thomas KJ, Baekelandt V, Cookson MR. Greggio E, et al. Among authors: cookson mr. J Biol Chem. 2008 Jun 13;283(24):16906-14. doi: 10.1074/jbc.M708718200. Epub 2008 Apr 8. J Biol Chem. 2008. PMID: 18397888 Free PMC article.

5

The Parkinson's disease associated LRRK2 exhibits weaker in vitro phosphorylation of 4E-BP compared to autophosphorylation.

Kumar A, Greggio E, Beilina A, Kaganovich A, Chan D, Taymans JM, Wolozin B, Cookson MR. Kumar A, et al. Among authors: cookson mr. PLoS One. 2010 Jan 15;5(1):e8730. doi: 10.1371/journal.pone.0008730. PLoS One. 2010. PMID: 20090955 Free PMC article.

6

The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation.

Rudenko IN, Kaganovich A, Hauser DN, Beylina A, Chia R, Ding J, Maric D, Jaffe H, Cookson MR. Rudenko IN, et al. Among authors: cookson mr. Biochem J. 2012 Aug 15;446(1):99-111. doi: 10.1042/BJ20120637. Biochem J. 2012. PMID: 22612223 Free PMC article.

7

Hexokinase activity is required for recruitment of parkin to depolarized mitochondria.

McCoy MK, Kaganovich A, Rudenko IN, Ding J, Cookson MR. McCoy MK, et al. Among authors: cookson mr. Hum Mol Genet. 2014 Jan 1;23(1):145-56. doi: 10.1093/hmg/ddt407. Epub 2013 Aug 19. Hum Mol Genet. 2014. PMID: 23962723 Free PMC article.

8

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.

Chia R, Haddock S, Beilina A, Rudenko IN, Mamais A, Kaganovich A, Li Y, Kumaran R, Nalls MA, Cookson MR. Chia R, et al. Among authors: cookson mr. Nat Commun. 2014 Dec 15;5:5827. doi: 10.1038/ncomms6827. Nat Commun. 2014. PMID: 25500533 Free PMC article.

9

The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.

Hauser DN, Primiani CT, Langston RG, Kumaran R, Cookson MR. Hauser DN, et al. Among authors: cookson mr. eNeuro. 2015 Mar 23;2(1):ENEURO.0075-14.2015. doi: 10.1523/ENEURO.0075-14.2015. eCollection 2015 Jan-Feb. eNeuro. 2015. PMID: 26464968 Free PMC article.

10

The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.

Langston RG, Rudenko IN, Cookson MR. Langston RG, et al. Among authors: cookson mr. Biochem J. 2016 Feb 1;473(3):221-32. doi: 10.1042/BJ20150985. Biochem J. 2016. PMID: 26811536 Free PMC article. Review.

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