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A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
Boudreau MW, Duraki D, Wang L, Mao C, Kim JE, Henn MA, Tang B, Fanning SW, Kiefer J, Tarasow TM, Bruckheimer EM, Moreno R, Mousses S, Greene GL, Roy EJ, Park BH, Fan TM, Nelson ER, Hergenrother PJ, Shapiro DJ. Boudreau MW, et al. Among authors: kiefer j. Sci Transl Med. 2021 Jul 21;13(603):eabf1383. doi: 10.1126/scitranslmed.abf1383. Sci Transl Med. 2021. PMID: 34290053 Free PMC article.
The Year in Cardiothoracic Critical Care: Highlighted Publications From 2023.
Kumar SU, Kiefer JJ, Moitra V, Migliore C, Rasheed M, Wallisch J, Gessouroun A, Flynn BC. Kumar SU, et al. Among authors: kiefer jj. J Cardiothorac Vasc Anesth. 2024 Dec;38(12):2900-2905. doi: 10.1053/j.jvca.2024.07.050. Epub 2024 Oct 18. J Cardiothorac Vasc Anesth. 2024. PMID: 39580204 Review.
A single-chain variable fragment-based bispecific T-cell activating antibody against CD117 enables T-cell mediated lysis of acute myeloid leukemia and hematopoietic stem and progenitor cells.
Volta L, Myburgh R, Hofstetter M, Koch C, Kiefer JD, Gobbi C, Manfredi F, Zimmermann K, Kaufmann P, Fazio S, Pellegrino C, Russkamp NF, Villars D, Matasci M, Maurer M, Mueller J, Schneiter F, Büschl P, Harrer N, Mock J, Balabanov S, Nombela-Arrieta C, Schroeder T, Neri D, Manz MG. Volta L, et al. Among authors: kiefer jd. Hemasphere. 2024 Nov 19;8(11):e70055. doi: 10.1002/hem3.70055. eCollection 2024 Nov. Hemasphere. 2024. PMID: 39564539 Free PMC article.
Discovery of GNE-6893, a Potent, Selective, Orally Bioavailable Small Molecule Inhibitor of HPK1.
Tellis JC, Wei B, Siu M, An L, Chan GK, Chen Y, Du X, Gazzard L, Hu B, Kiefer J, Kakiuchi-Kiyota S, Lainchbury M, Linehan JL, Luo X, Malhotra S, Mendonca R, Pang J, Ran Y, Sethuraman V, Seward E, Sneeringer C, Su D, Wang W, Wu P, Moffat JG, Heffron TP, Choo EF, Chan BK. Tellis JC, et al. Among authors: kiefer j. ACS Med Chem Lett. 2024 Sep 3;15(9):1606-1614. doi: 10.1021/acsmedchemlett.4c00319. eCollection 2024 Sep 12. ACS Med Chem Lett. 2024. PMID: 39291002
647 results