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A small-molecule activator of the unfolded protein response eradicates human breast tumors in mice.
Boudreau MW, Duraki D, Wang L, Mao C, Kim JE, Henn MA, Tang B, Fanning SW, Kiefer J, Tarasow TM, Bruckheimer EM, Moreno R, Mousses S, Greene GL, Roy EJ, Park BH, Fan TM, Nelson ER, Hergenrother PJ, Shapiro DJ. Boudreau MW, et al. Among authors: hergenrother pj. Sci Transl Med. 2021 Jul 21;13(603):eabf1383. doi: 10.1126/scitranslmed.abf1383. Sci Transl Med. 2021. PMID: 34290053 Free PMC article.
A new small molecule inhibitor of estrogen receptor alpha binding to estrogen response elements blocks estrogen-dependent growth of cancer cells.
Mao C, Patterson NM, Cherian MT, Aninye IO, Zhang C, Montoya JB, Cheng J, Putt KS, Hergenrother PJ, Wilson EM, Nardulli AM, Nordeen SK, Shapiro DJ. Mao C, et al. Among authors: hergenrother pj. J Biol Chem. 2008 May 9;283(19):12819-30. doi: 10.1074/jbc.M709936200. Epub 2008 Mar 12. J Biol Chem. 2008. PMID: 18337247 Free PMC article.
Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs.
Lucas PW, Schmit JM, Peterson QP, West DC, Hsu DC, Novotny CJ, Dirikolu L, Churchwell MI, Doerge DR, Garrett LD, Hergenrother PJ, Fan TM. Lucas PW, et al. Among authors: hergenrother pj. Invest New Drugs. 2011 Oct;29(5):901-11. doi: 10.1007/s10637-010-9445-z. Epub 2010 May 25. Invest New Drugs. 2011. PMID: 20499133 Free PMC article.
A noncompetitive small molecule inhibitor of estrogen-regulated gene expression and breast cancer cell growth that enhances proteasome-dependent degradation of estrogen receptor {alpha}.
Kretzer NM, Cherian MT, Mao C, Aninye IO, Reynolds PD, Schiff R, Hergenrother PJ, Nordeen SK, Wilson EM, Shapiro DJ. Kretzer NM, et al. Among authors: hergenrother pj. J Biol Chem. 2010 Dec 31;285(53):41863-73. doi: 10.1074/jbc.M110.183723. Epub 2010 Nov 1. J Biol Chem. 2010. PMID: 21041310 Free PMC article.
A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.
Palchaudhuri R, Lambrecht MJ, Botham RC, Partlow KC, van Ham TJ, Putt KS, Nguyen LT, Kim SH, Peterson RT, Fan TM, Hergenrother PJ. Palchaudhuri R, et al. Among authors: hergenrother pj. Cell Rep. 2015 Dec 1;13(9):2027-36. doi: 10.1016/j.celrep.2015.10.042. Epub 2015 Nov 19. Cell Rep. 2015. PMID: 26655912 Free PMC article.
191 results