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Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain.
Ma XR, Xu L, Xu S, Klein BJ, Wang H, Das S, Li K, Yang KS, Sohail S, Chapman A, Kutateladze TG, Shi X, Liu WR, Wen H. Ma XR, et al. Among authors: kutateladze tg. J Med Chem. 2021 Aug 12;64(15):10997-11013. doi: 10.1021/acs.jmedchem.1c00367. Epub 2021 Jul 19. J Med Chem. 2021. PMID: 34279931 Free PMC article.
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.
Klein BJ, Piao L, Xi Y, Rincon-Arano H, Rothbart SB, Peng D, Wen H, Larson C, Zhang X, Zheng X, Cortazar MA, Peña PV, Mangan A, Bentley DL, Strahl BD, Groudine M, Li W, Shi X, Kutateladze TG. Klein BJ, et al. Among authors: kutateladze tg. Cell Rep. 2014 Jan 30;6(2):325-35. doi: 10.1016/j.celrep.2013.12.021. Epub 2014 Jan 9. Cell Rep. 2014. PMID: 24412361 Free PMC article.
The Taf14 YEATS domain is a reader of histone crotonylation.
Andrews FH, Shinsky SA, Shanle EK, Bridgers JB, Gest A, Tsun IK, Krajewski K, Shi X, Strahl BD, Kutateladze TG. Andrews FH, et al. Among authors: kutateladze tg. Nat Chem Biol. 2016 Jun;12(6):396-8. doi: 10.1038/nchembio.2065. Epub 2016 Apr 18. Nat Chem Biol. 2016. PMID: 27089029 Free PMC article.
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
Zhu L, Li Q, Wong SH, Huang M, Klein BJ, Shen J, Ikenouye L, Onishi M, Schneidawind D, Buechele C, Hansen L, Duque-Afonso J, Zhu F, Martin GM, Gozani O, Majeti R, Kutateladze TG, Cleary ML. Zhu L, et al. Among authors: kutateladze tg. Cancer Discov. 2016 Jul;6(7):770-83. doi: 10.1158/2159-8290.CD-16-0058. Epub 2016 May 6. Cancer Discov. 2016. PMID: 27154821 Free PMC article.
197 results