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Multitarget drug discovery for tuberculosis and other infectious diseases.
Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes FL, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu YL, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo RT, Cole ST, Gennis RB, Crick DC, Oldfield E. Li K, et al. Among authors: oldfield e. J Med Chem. 2014 Apr 10;57(7):3126-39. doi: 10.1021/jm500131s. Epub 2014 Apr 1. J Med Chem. 2014. PMID: 24568559 Free PMC article.
Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5.
Zhang L, Chen CC, Ko TP, Huang JW, Zheng Y, Liu W, Wang I, Malwal SR, Feng X, Wang K, Huang CH, Hsu ST, Wang AH, Oldfield E, Guo RT. Zhang L, et al. Among authors: oldfield e. Angew Chem Int Ed Engl. 2016 Apr 4;55(15):4716-20. doi: 10.1002/anie.201511388. Epub 2016 Mar 8. Angew Chem Int Ed Engl. 2016. PMID: 26954060 Free PMC article.
Isoprenoid Biosynthesis Inhibitors Targeting Bacterial Cell Growth.
Desai J, Wang Y Dr, Wang K Dr, Malwal SR Dr, Oldfield E. Desai J, et al. Among authors: oldfield e. ChemMedChem. 2016 Oct 6;11(19):2205-2215. doi: 10.1002/cmdc.201600343. Epub 2016 Aug 30. ChemMedChem. 2016. PMID: 27571880 Free PMC article.
Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).
Elsebaei MM, Mohammad H, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS. Elsebaei MM, et al. Among authors: oldfield e. Eur J Med Chem. 2018 Mar 25;148:195-209. doi: 10.1016/j.ejmech.2018.02.031. Epub 2018 Feb 12. Eur J Med Chem. 2018. PMID: 29459278 Free PMC article.
931 results