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A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration.
Tautou M, Eddarkaoui S, Descamps F, Larchanché PE, El Bakali J, Goveas LM, Dumoulin M, Lamarre C, Blum D, Buée L, Melnyk P, Sergeant N. Tautou M, et al. Among authors: larchanche pe. Front Pharmacol. 2021 Jun 29;12:679335. doi: 10.3389/fphar.2021.679335. eCollection 2021. Front Pharmacol. 2021. PMID: 34267657 Free PMC article.
Chloroquine and chloroquinoline derivatives as models for the design of modulators of amyloid Peptide precursor metabolism.
Melnyk P, Vingtdeux V, Burlet S, Eddarkaoui S, Grosjean ME, Larchanché PE, Hochart G, Sergheraert C, Estrella C, Barrier M, Poix V, Plancq P, Lannoo C, Hamdane M, Delacourte A, Verwaerde P, Buée L, Sergeant N. Melnyk P, et al. Among authors: larchanche pe. ACS Chem Neurosci. 2015 Apr 15;6(4):559-69. doi: 10.1021/cn5003013. Epub 2015 Feb 6. ACS Chem Neurosci. 2015. PMID: 25611616
A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors.
Gay M, Evrard C, Descamps F, Carato P, Renault N, Coevoet M, Eddarkaoui S, Baud C, Larchanché PE, Buée L, El Bakali J, Vingtdeux V, Sergeant N, Melnyk P. Gay M, et al. Among authors: larchanche pe. Eur J Med Chem. 2018 Nov 5;159:104-125. doi: 10.1016/j.ejmech.2018.08.092. Epub 2018 Sep 22. Eur J Med Chem. 2018. PMID: 30268822
New piperazine multi-effect drugs prevent neurofibrillary degeneration and amyloid deposition, and preserve memory in animal models of Alzheimer's disease.
Sergeant N, Vingtdeux V, Eddarkaoui S, Gay M, Evrard C, Le Fur N, Laurent C, Caillierez R, Obriot H, Larchanché PE, Farce A, Coevoet M, Carato P, Kouach M, Descat A, Dallemagne P, Buée-Scherrer V, Blum D, Hamdane M, Buée L, Melnyk P. Sergeant N, et al. Among authors: larchanche pe. Neurobiol Dis. 2019 Sep;129:217-233. doi: 10.1016/j.nbd.2019.03.028. Epub 2019 Mar 27. Neurobiol Dis. 2019. PMID: 30928644
Discovery of Compounds That Selectively Repress the Amyloidogenic Processing of the Amyloid Precursor Protein: Design, Synthesis and Pharmacological Evaluation of Diphenylpyrazoles.
Mesangeau C, Carato P, Renault N, Coevoet M, Larchanché PE, Barczyk A, Buée L, Sergeant N, Melnyk P. Mesangeau C, et al. Among authors: larchanche pe. Int J Mol Sci. 2022 Oct 28;23(21):13111. doi: 10.3390/ijms232113111. Int J Mol Sci. 2022. PMID: 36361896 Free PMC article.
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