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Prolyl-4-hydroxylase 3 maintains β cell glucose metabolism during fatty acid excess in mice.
Nasteska D, Cuozzo F, Viloria K, Johnson EM, Thakker A, Bany Bakar R, Westbrook RL, Barlow JP, Hoang M, Joseph JW, Lavery GG, Akerman I, Cantley J, Hodson L, Tennant DA, Hodson DJ. Nasteska D, et al. Among authors: westbrook rl. JCI Insight. 2021 Aug 23;6(16):e140288. doi: 10.1172/jci.insight.140288. JCI Insight. 2021. PMID: 34264866 Free PMC article.
New aspects of amino acid metabolism in cancer.
Vettore L, Westbrook RL, Tennant DA. Vettore L, et al. Among authors: westbrook rl. Br J Cancer. 2020 Jan;122(2):150-156. doi: 10.1038/s41416-019-0620-5. Epub 2019 Dec 10. Br J Cancer. 2020. PMID: 31819187 Free PMC article. Review.
Proline synthesis through PYCR1 is required to support cancer cell proliferation and survival in oxygen-limiting conditions.
Westbrook RL, Bridges E, Roberts J, Escribano-Gonzalez C, Eales KL, Vettore LA, Walker PD, Vera-Siguenza E, Rana H, Cuozzo F, Eskla KL, Vellama H, Shaaban A, Nixon C, Luuk H, Lavery GG, Hodson DJ, Harris AL, Tennant DA. Westbrook RL, et al. Cell Rep. 2022 Feb 1;38(5):110320. doi: 10.1016/j.celrep.2022.110320. Cell Rep. 2022. PMID: 35108535 Free PMC article.