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Molecular phenotyping and functional assessment of smooth muscle-like cells with pathogenic variants in aneurysm genes ACTA2, MYH11, SMAD3 and FBN1.
Burger J, Bogunovic N, de Wagenaar NP, Liu H, van Vliet N, IJpma A, Maugeri A, Micha D, Verhagen HJM, Ten Hagen TLM, Majoor-Krakauer D, van der Pluijm I, Essers J, Yeung KK. Burger J, et al. Among authors: ten hagen tlm. Hum Mol Genet. 2021 Nov 16;30(23):2286-2299. doi: 10.1093/hmg/ddab190. Hum Mol Genet. 2021. PMID: 34244757 Free PMC article.
Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.
Krawczyk PM, Eppink B, Essers J, Stap J, Rodermond H, Odijk H, Zelensky A, van Bree C, Stalpers LJ, Buist MR, Soullié T, Rens J, Verhagen HJ, O'Connor MJ, Franken NA, Ten Hagen TL, Kanaar R, Aten JA. Krawczyk PM, et al. Proc Natl Acad Sci U S A. 2011 Jun 14;108(24):9851-6. doi: 10.1073/pnas.1101053108. Epub 2011 May 9. Proc Natl Acad Sci U S A. 2011. PMID: 21555554 Free PMC article.
Forced expression of HOXA13 confers oncogenic hallmarks to esophageal keratinocytes.
Nesteruk K, Janmaat VT, Liu H, Ten Hagen TLM, Peppelenbosch MP, Fuhler GM. Nesteruk K, et al. Among authors: ten hagen tlm. Biochim Biophys Acta Mol Basis Dis. 2020 Aug 1;1866(8):165776. doi: 10.1016/j.bbadis.2020.165776. Epub 2020 Mar 25. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 32222541 Free article.
PDGF-induced migration of vascular smooth muscle cells is inhibited by heme oxygenase-1 via VEGFR2 upregulation and subsequent assembly of inactive VEGFR2/PDGFRβ heterodimers.
Cheng C, Haasdijk RA, Tempel D, den Dekker WK, Chrifi I, Blonden LA, van de Kamp EH, de Boer M, Bürgisser PE, Noorderloos A, Rens JA, ten Hagen TL, Duckers HJ. Cheng C, et al. Arterioscler Thromb Vasc Biol. 2012 May;32(5):1289-98. doi: 10.1161/ATVBAHA.112.245530. Epub 2012 Mar 15. Arterioscler Thromb Vasc Biol. 2012. PMID: 22426130
SMAD4 exerts a tumor-promoting role in hepatocellular carcinoma.
Hernanda PY, Chen K, Das AM, Sideras K, Wang W, Li J, Cao W, Bots SJ, Kodach LL, de Man RA, Ijzermans JN, Janssen HL, Stubbs AP, Sprengers D, Bruno MJ, Metselaar HJ, ten Hagen TL, Kwekkeboom J, Peppelenbosch MP, Pan Q. Hernanda PY, et al. Oncogene. 2015 Sep 24;34(39):5055-68. doi: 10.1038/onc.2014.425. Epub 2014 Dec 22. Oncogene. 2015. PMID: 25531314
209 results