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E-type prostanoid receptor 4 drives resolution of intestinal inflammation by blocking epithelial necroptosis.
Patankar JV, Müller TM, Kantham S, Acera MG, Mascia F, Scheibe K, Mahapatro M, Heichler C, Yu Y, Li W, Ruder B, Günther C, Leppkes M, Mathew MJ, Wirtz S, Neufert C, Kühl AA, Paquette J, Jacobson K, Atreya R, Zundler S, Neurath MF, Young RN, Becker C. Patankar JV, et al. Among authors: leppkes m. Nat Cell Biol. 2021 Jul;23(7):796-807. doi: 10.1038/s41556-021-00708-8. Epub 2021 Jul 8. Nat Cell Biol. 2021. PMID: 34239062
STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing.
Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, Warntjen M, Lehr HA, Hirth S, Weigmann B, Wirtz S, Ouyang W, Neurath MF, Becker C. Pickert G, et al. Among authors: leppkes m. J Exp Med. 2009 Jul 6;206(7):1465-72. doi: 10.1084/jem.20082683. Epub 2009 Jun 29. J Exp Med. 2009. PMID: 19564350 Free PMC article.
Tumor fibroblast-derived epiregulin promotes growth of colitis-associated neoplasms through ERK.
Neufert C, Becker C, Türeci Ö, Waldner MJ, Backert I, Floh K, Atreya I, Leppkes M, Jefremow A, Vieth M, Schneider-Stock R, Klinger P, Greten FR, Threadgill DW, Sahin U, Neurath MF. Neufert C, et al. Among authors: leppkes m. J Clin Invest. 2013 Apr;123(4):1428-43. doi: 10.1172/JCI63748. Epub 2013 Mar 15. J Clin Invest. 2013. PMID: 23549083 Free PMC article.
[Toxic megacolon].
Leppkes M, Ganslmayer M, Strauß R, Neurath MF. Leppkes M, et al. Med Klin Intensivmed Notfmed. 2015 Oct;110(7):500-5. doi: 10.1007/s00063-015-0076-1. Epub 2015 Sep 14. Med Klin Intensivmed Notfmed. 2015. PMID: 26369529 Review. German.
Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis.
Leppkes M, Maueröder C, Hirth S, Nowecki S, Günther C, Billmeier U, Paulus S, Biermann M, Munoz LE, Hoffmann M, Wildner D, Croxford AL, Waisman A, Mowen K, Jenne DE, Krenn V, Mayerle J, Lerch MM, Schett G, Wirtz S, Neurath MF, Herrmann M, Becker C. Leppkes M, et al. Nat Commun. 2016 Mar 11;7:10973. doi: 10.1038/ncomms10973. Nat Commun. 2016. PMID: 26964500 Free PMC article.
62 results