Fairbrother WJ - Search Results

1

Primary Amine Tethered Small Molecules Promote the Degradation of X-Linked Inhibitor of Apoptosis Protein.

den Besten W, Verma K, Yamazoe S, Blaquiere N, Phung W, Izrael-Tomasevic A, Mulvihill MM, Helgason E, Prakash S, Goncharov T, Vucic D, Dueber E, Fairbrother WJ, Wertz I, Yu K, Staben ST. den Besten W, et al. Among authors: fairbrother wj. J Am Chem Soc. 2021 Jul 21;143(28):10571-10575. doi: 10.1021/jacs.1c05269. Epub 2021 Jul 8. J Am Chem Soc. 2021. PMID: 34236858

2

Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

Vucic D, Franklin MC, Wallweber HJ, Das K, Eckelman BP, Shin H, Elliott LO, Kadkhodayan S, Deshayes K, Salvesen GS, Fairbrother WJ. Vucic D, et al. Among authors: fairbrother wj. Biochem J. 2005 Jan 1;385(Pt 1):11-20. doi: 10.1042/BJ20041108. Biochem J. 2005. PMID: 15485396 Free PMC article.

3

The inhibitor of apoptosis protein fusion c-IAP2.MALT1 stimulates NF-kappaB activation independently of TRAF1 AND TRAF2.

Varfolomeev E, Wayson SM, Dixit VM, Fairbrother WJ, Vucic D. Varfolomeev E, et al. Among authors: fairbrother wj. J Biol Chem. 2006 Sep 29;281(39):29022-9. doi: 10.1074/jbc.M605116200. Epub 2006 Aug 4. J Biol Chem. 2006. PMID: 16891304 Free article.

4

Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

Zobel K, Wang L, Varfolomeev E, Franklin MC, Elliott LO, Wallweber HJ, Okawa DC, Flygare JA, Vucic D, Fairbrother WJ, Deshayes K. Zobel K, et al. Among authors: fairbrother wj. ACS Chem Biol. 2006 Sep 19;1(8):525-33. doi: 10.1021/cb600276q. ACS Chem Biol. 2006. PMID: 17168540

5

The inhibitor of apoptosis proteins as therapeutic targets in cancer.

Vucic D, Fairbrother WJ. Vucic D, et al. Among authors: fairbrother wj. Clin Cancer Res. 2007 Oct 15;13(20):5995-6000. doi: 10.1158/1078-0432.CCR-07-0729. Clin Cancer Res. 2007. PMID: 17947460 Review.

6

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1).

Blankenship JW, Varfolomeev E, Goncharov T, Fedorova AV, Kirkpatrick DS, Izrael-Tomasevic A, Phu L, Arnott D, Aghajan M, Zobel K, Bazan JF, Fairbrother WJ, Deshayes K, Vucic D. Blankenship JW, et al. Among authors: fairbrother wj. Biochem J. 2009 Jan 1;417(1):149-60. doi: 10.1042/BJ20081885. Biochem J. 2009. PMID: 18939944

7

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.

Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ. Cohen F, et al. Among authors: fairbrother wj. J Med Chem. 2009 Mar 26;52(6):1723-30. doi: 10.1021/jm801450c. J Med Chem. 2009. PMID: 19228017

8

Antagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonists.

Ndubaku C, Varfolomeev E, Wang L, Zobel K, Lau K, Elliott LO, Maurer B, Fedorova AV, Dynek JN, Koehler M, Hymowitz SG, Tsui V, Deshayes K, Fairbrother WJ, Flygare JA, Vucic D. Ndubaku C, et al. Among authors: fairbrother wj. ACS Chem Biol. 2009 Jul 17;4(7):557-66. doi: 10.1021/cb900083m. ACS Chem Biol. 2009. PMID: 19492850

9

X chromosome-linked inhibitor of apoptosis regulates cell death induction by proapoptotic receptor agonists.

Varfolomeev E, Alicke B, Elliott JM, Zobel K, West K, Wong H, Scheer JM, Ashkenazi A, Gould SE, Fairbrother WJ, Vucic D. Varfolomeev E, et al. Among authors: fairbrother wj. J Biol Chem. 2009 Dec 11;284(50):34553-60. doi: 10.1074/jbc.M109.040139. Epub 2009 Oct 23. J Biol Chem. 2009. PMID: 19854829 Free PMC article.

10

c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling.

Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D. Dynek JN, et al. Among authors: fairbrother wj. EMBO J. 2010 Dec 15;29(24):4198-209. doi: 10.1038/emboj.2010.300. Epub 2010 Nov 26. EMBO J. 2010. PMID: 21113135 Free PMC article.

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