Islam S - Search Results

1

Repurposing existing therapeutics, its importance in oncology drug development: Kinases as a potential target.

Islam S, Wang S, Bowden N, Martin J, Head R. Islam S, et al. Br J Clin Pharmacol. 2022 Jan;88(1):64-74. doi: 10.1111/bcp.14964. Epub 2021 Jul 9. Br J Clin Pharmacol. 2022. PMID: 34192364 Free PMC article. Review.

2

Inhibition of Mnk enhances apoptotic activity of cytarabine in acute myeloid leukemia cells.

Li P, Diab S, Yu M, Adams J, Islam S, Basnet SK, Albrecht H, Milne R, Wang S. Li P, et al. Among authors: islam s. Oncotarget. 2016 Aug 30;7(35):56811-56825. doi: 10.18632/oncotarget.10796. Oncotarget. 2016. PMID: 27462781 Free PMC article.

3

Synthesis and biological evaluation of heteroaryl styryl sulfone derivatives as anticancer agents.

Long Y, Yu M, Li P, Islam S, Goh AW, Kumarasiri M, Wang S. Long Y, et al. Among authors: islam s. Bioorg Med Chem Lett. 2016 Dec 1;26(23):5674-5678. doi: 10.1016/j.bmcl.2016.10.062. Epub 2016 Oct 24. Bioorg Med Chem Lett. 2016. PMID: 27815119

4

Highly Potent, Selective, and Orally Bioavailable 4-Thiazol-N-(pyridin-2-yl)pyrimidin-2-amine Cyclin-Dependent Kinases 4 and 6 Inhibitors as Anticancer Drug Candidates: Design, Synthesis, and Evaluation.

Tadesse S, Yu M, Mekonnen LB, Lam F, Islam S, Tomusange K, Rahaman MH, Noll B, Basnet SK, Teo T, Albrecht H, Milne R, Wang S. Tadesse S, et al. Among authors: islam s. J Med Chem. 2017 Mar 9;60(5):1892-1915. doi: 10.1021/acs.jmedchem.6b01670. Epub 2017 Feb 16. J Med Chem. 2017. PMID: 28156111 Free article.

5

Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents.

Tadesse S, Bantie L, Tomusange K, Yu M, Islam S, Bykovska N, Noll B, Zhu G, Li P, Lam F, Kumarasiri M, Milne R, Wang S. Tadesse S, et al. Among authors: islam s. Br J Pharmacol. 2018 Jun;175(12):2399-2413. doi: 10.1111/bph.13974. Epub 2018 May 8. Br J Pharmacol. 2018. PMID: 28800675 Free PMC article.

6

Discovery of N-Phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity.

Abdelaziz AM, Diab S, Islam S, Basnet SKC, Noll B, Li P, Mekonnen LB, Lu J, Albrecht H, Milne RW, Gerber C, Yu M, Wang S. Abdelaziz AM, et al. Among authors: islam s. Med Chem. 2019;15(6):602-623. doi: 10.2174/1573406415666181219111511. Med Chem. 2019. PMID: 30569866

7

Synthesis and evaluation of 2'H-spiro[cyclohexane-1,3'-imidazo[1,5-a]pyridine]-1',5'-dione derivatives as Mnk inhibitors.

Abdelaziz AM, Basnet SKC, Islam S, Li M, Tadesse S, Albrecht H, Gerber C, Yu M, Wang S. Abdelaziz AM, et al. Among authors: islam s. Bioorg Med Chem Lett. 2019 Sep 15;29(18):2650-2654. doi: 10.1016/j.bmcl.2019.07.043. Epub 2019 Jul 23. Bioorg Med Chem Lett. 2019. PMID: 31362920

8

Systems analysis shows that thermodynamic physiological and pharmacological fundamentals drive COVID-19 and response to treatment.

Head RJ, Lumbers ER, Jarrott B, Tretter F, Smith G, Pringle KG, Islam S, Martin JH. Head RJ, et al. Among authors: islam s. Pharmacol Res Perspect. 2022 Feb;10(1):e00922. doi: 10.1002/prp2.922. Pharmacol Res Perspect. 2022. PMID: 35106955 Free PMC article. Review.

9

Combined In Silico and In Vitro Evidence Supporting an Aurora A Kinase Inhibitory Role of the Anti-Viral Drug Rilpivirine and an Anti-Proliferative Influence on Cancer Cells.

Islam S, Teo T, Kumarasiri M, Slater M, Martin JH, Wang S, Head R. Islam S, et al. Pharmaceuticals (Basel). 2022 Sep 25;15(10):1186. doi: 10.3390/ph15101186. Pharmaceuticals (Basel). 2022. PMID: 36297298 Free PMC article.

10

Anti-Leukaemic Activity of Rilpivirine Is Mediated by Aurora A Kinase Inhibition.

Islam S, Rahaman MH, Yu M, Noll B, Martin JH, Wang S, Head R. Islam S, et al. Cancers (Basel). 2023 Feb 7;15(4):1044. doi: 10.3390/cancers15041044. Cancers (Basel). 2023. PMID: 36831387 Free PMC article.

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