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RelA-SpoT Homolog toxins pyrophosphorylate the CCA end of tRNA to inhibit protein synthesis.
Kurata T, Brodiazhenko T, Alves Oliveira SR, Roghanian M, Sakaguchi Y, Turnbull KJ, Bulvas O, Takada H, Tamman H, Ainelo A, Pohl R, Rejman D, Tenson T, Suzuki T, Garcia-Pino A, Atkinson GC, Hauryliuk V. Kurata T, et al. Mol Cell. 2021 Aug 5;81(15):3160-3170.e9. doi: 10.1016/j.molcel.2021.06.005. Epub 2021 Jun 25. Mol Cell. 2021. PMID: 34174184 Free article.
A widespread toxin-antitoxin system exploiting growth control via alarmone signaling.
Jimmy S, Saha CK, Kurata T, Stavropoulos C, Oliveira SRA, Koh A, Cepauskas A, Takada H, Rejman D, Tenson T, Strahl H, Garcia-Pino A, Hauryliuk V, Atkinson GC. Jimmy S, et al. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10500-10510. doi: 10.1073/pnas.1916617117. Epub 2020 Apr 28. Proc Natl Acad Sci U S A. 2020. PMID: 32345719 Free PMC article.
85 results