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Canonical IRE1 function needed to sustain vigorous natural killer cell proliferation during viral infection.
Vetters J, van Helden M, De Nolf C, Rennen S, Cloots E, Van De Velde E, Fayazpour F, Van Moorleghem J, Vanheerswynghels M, Vergote K, Boon L, Vivier E, Lambrecht BN, Janssens S. Vetters J, et al. Among authors: van helden m. iScience. 2023 Nov 23;26(12):108570. doi: 10.1016/j.isci.2023.108570. eCollection 2023 Dec 15. iScience. 2023. PMID: 38162021 Free PMC article.
BYON4228 is a pan-allelic antagonistic SIRPα antibody that potentiates destruction of antibody-opsonized tumor cells and lacks binding to SIRPγ on T cells.
van Helden MJ, Zwarthoff SA, Arends RJ, Reinieren-Beeren IMJ, Paradé MCBC, Driessen-Engels L, de Laat-Arts K, Damming D, Santegoeds-Lenssen EWH, van Kuppeveld DWJ, Lodewijks I, Olsman H, Matlung HL, Franke K, Mattaar-Hepp E, Stokman MEM, de Wit B, Glaudemans DHRF, van Wijk DEJW, Joosten-Stoffels L, Schouten J, Boersema PJ, van der Vleuten M, Sanderink JWH, Kappers WA, van den Dobbelsteen D, Timmers M, Ubink R, Rouwendal GJA, Verheijden G, van der Lee MMC, Dokter WHA, van den Berg TK. van Helden MJ, et al. J Immunother Cancer. 2023 Apr;11(4):e006567. doi: 10.1136/jitc-2022-006567. J Immunother Cancer. 2023. PMID: 37068796 Free PMC article.
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
Bosteels C, Neyt K, Vanheerswynghels M, van Helden MJ, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams DL, Tang SC, Mayer JU, Ronchese F, Scott CL, Hammad H, Guilliams M, Lambrecht BN. Bosteels C, et al. Among authors: van helden mj. Immunity. 2020 Jun 16;52(6):1039-1056.e9. doi: 10.1016/j.immuni.2020.04.005. Epub 2020 May 8. Immunity. 2020. PMID: 32392463 Free PMC article.
The ubiquitin-editing enzyme A20 controls NK cell homeostasis through regulation of mTOR activity and TNF.
Vetters J, van Helden MJ, Wahlen S, Tavernier SJ, Martens A, Fayazpour F, Vergote K, Vanheerswynghels M, Deswarte K, Van Moorleghem J, De Prijck S, Takahashi N, Vandenabeele P, Boon L, van Loo G, Vivier E, Lambrecht BN, Janssens S. Vetters J, et al. Among authors: van helden mj. J Exp Med. 2019 Sep 2;216(9):2010-2023. doi: 10.1084/jem.20182164. Epub 2019 Jul 11. J Exp Med. 2019. PMID: 31296735 Free PMC article.
40 results