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Analogues of the anti-malaria drug mefloquine have broad spectrum antifungal activity and are efficacious in a model of disseminated Candida auris infection.
Guin S, Montoya MC, Wang X, Zarnowski R, Andes DR, Meyers MJ, Williams NS, Krysan DJ. Guin S, et al. Among authors: krysan dj. bioRxiv [Preprint]. 2024 Aug 30:2024.08.29.610379. doi: 10.1101/2024.08.29.610379. bioRxiv. 2024. Update in: Antimicrob Agents Chemother. 2024 Nov 6;68(11):e0130124. doi: 10.1128/aac.01301-24. PMID: 39257751 Free PMC article. Updated. Preprint.
Candida albicans triggers NLRP3-mediated pyroptosis in macrophages.
Wellington M, Koselny K, Sutterwala FS, Krysan DJ. Wellington M, et al. Among authors: krysan dj. Eukaryot Cell. 2014 Feb;13(2):329-40. doi: 10.1128/EC.00336-13. Epub 2013 Dec 27. Eukaryot Cell. 2014. PMID: 24376002 Free PMC article.
Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE Jr, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. Butts A, et al. Among authors: krysan dj. mBio. 2014 Feb 11;5(1):e00765-13. doi: 10.1128/mBio.00765-13. mBio. 2014. PMID: 24520056 Free PMC article.
Catching fire: Candida albicans, macrophages, and pyroptosis.
Krysan DJ, Sutterwala FS, Wellington M. Krysan DJ, et al. PLoS Pathog. 2014 Jun 26;10(6):e1004139. doi: 10.1371/journal.ppat.1004139. eCollection 2014 Jun. PLoS Pathog. 2014. PMID: 24967821 Free PMC article. No abstract available.
The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. Koselny K, et al. Among authors: krysan dj. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7115-7127. doi: 10.1128/AAC.01061-16. Print 2016 Dec. Antimicrob Agents Chemother. 2016. PMID: 27645246 Free PMC article.
124 results