Herpers B - Search Results

1

New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids.

Rodrigues D, de Souza T, Coyle L, Di Piazza M, Herpers B, Ferreira S, Zhang M, Vappiani J, Sévin DC, Gabor A, Lynch A, Chung SW, Saez-Rodriguez J, Jennen DGJ, Kleinjans JCS, de Kok TM. Rodrigues D, et al. Among authors: herpers b. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20. Arch Toxicol. 2021. PMID: 34151400 Free PMC article.

2

Unravelling Mechanisms of Doxorubicin-Induced Toxicity in 3D Human Intestinal Organoids.

Rodrigues D, Coyle L, Füzi B, Ferreira S, Jo H, Herpers B, Chung SW, Fisher C, Kleinjans JCS, Jennen D, de Kok TM. Rodrigues D, et al. Among authors: herpers b. Int J Mol Sci. 2022 Jan 24;23(3):1286. doi: 10.3390/ijms23031286. Int J Mol Sci. 2022. PMID: 35163210 Free PMC article.

3

A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids.

Rodrigues D, Herpers B, Ferreira S, Jo H, Fisher C, Coyle L, Chung SW, Kleinjans JCS, Jennen DGJ, de Kok TM. Rodrigues D, et al. Among authors: herpers b. Int J Mol Sci. 2022 Feb 17;23(4):2213. doi: 10.3390/ijms23042213. Int J Mol Sci. 2022. PMID: 35216325 Free PMC article.

4

Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants.

Jardi F, Kelly C, Teague C, Fowler-Williams H, Sevin DC, Rodrigues D, Jo H, Ferreira S, Herpers B, Van Heerden M, de Kok T, Pin C, Lynch A, Duckworth CA, De Jonghe S, Lammens L, Pritchard DM. Jardi F, et al. Among authors: herpers b. Arch Toxicol. 2023 Jan;97(1):235-254. doi: 10.1007/s00204-022-03374-3. Epub 2022 Oct 6. Arch Toxicol. 2023. PMID: 36203040

5

High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities.

Wink S, Hiemstra S, Herpers B, van de Water B. Wink S, et al. Among authors: herpers b. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29. Arch Toxicol. 2017. PMID: 27358234 Free PMC article.

6

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.

Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, van de Water B, Price LS. Ramaiahgari SC, et al. Among authors: herpers b. Arch Toxicol. 2014 May;88(5):1083-95. doi: 10.1007/s00204-014-1215-9. Epub 2014 Mar 6. Arch Toxicol. 2014. PMID: 24599296

7

Activation of the Nrf2 response by intrinsic hepatotoxic drugs correlates with suppression of NF-κB activation and sensitizes toward TNFα-induced cytotoxicity.

Herpers B, Wink S, Fredriksson L, Di Z, Hendriks G, Vrieling H, de Bont H, van de Water B. Herpers B, et al. Arch Toxicol. 2016 May;90(5):1163-79. doi: 10.1007/s00204-015-1536-3. Epub 2015 May 31. Arch Toxicol. 2016. PMID: 26026609 Free PMC article.

8

Quantitative high content imaging of cellular adaptive stress response pathways in toxicity for chemical safety assessment.

Wink S, Hiemstra S, Huppelschoten S, Danen E, Niemeijer M, Hendriks G, Vrieling H, Herpers B, van de Water B. Wink S, et al. Among authors: herpers b. Chem Res Toxicol. 2014 Mar 17;27(3):338-55. doi: 10.1021/tx4004038. Epub 2014 Feb 5. Chem Res Toxicol. 2014. PMID: 24450961 Review.

9

AMAP, the alleged non-toxic isomer of acetaminophen, is toxic in rat and human liver.

Hadi M, Dragovic S, van Swelm R, Herpers B, van de Water B, Russel FG, Commandeur JN, Groothuis GM. Hadi M, et al. Among authors: herpers b. Arch Toxicol. 2013 Jan;87(1):155-65. doi: 10.1007/s00204-012-0924-1. Epub 2012 Aug 23. Arch Toxicol. 2013. PMID: 22914986

10

Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNFα-mediated hepatotoxicity.

Fredriksson L, Wink S, Herpers B, Benedetti G, Hadi M, de Bont H, Groothuis G, Luijten M, Danen E, de Graauw M, Meerman J, van de Water B. Fredriksson L, et al. Among authors: herpers b. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20. Toxicol Sci. 2014. PMID: 24752500

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