Zakharov AV - Search Results

1

Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells.

Alvarez-Gonzalez J, Yasgar A, Maul RW, Rieffer AE, Crawford DJ, Salamango DJ, Dorjsuren D, Zakharov AV, Jansen DJ, Rai G, Marugan J, Simeonov A, Harris RS, Kohli RM, Gearhart PJ. Alvarez-Gonzalez J, et al. Among authors: zakharov av. ACS Pharmacol Transl Sci. 2021 May 7;4(3):1214-1226. doi: 10.1021/acsptsci.1c00064. eCollection 2021 Jun 11. ACS Pharmacol Transl Sci. 2021. PMID: 34151211 Free PMC article.

2

An Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis Software.

Shah P, Kerns E, Nguyen DT, Obach RS, Wang AQ, Zakharov A, McKew J, Simeonov A, Hop CE, Xu X. Shah P, et al. Drug Metab Dispos. 2016 Oct;44(10):1653-61. doi: 10.1124/dmd.116.072017. Epub 2016 Jul 14. Drug Metab Dispos. 2016. PMID: 27417180 Free PMC article.

3

Cell Lysate-Based AlphaLISA Deubiquitinase Assay Platform for Identification of Small Molecule Inhibitors.

Ott CA, Baljinnyam B, Zakharov AV, Jadhav A, Simeonov A, Zhuang Z. Ott CA, et al. Among authors: zakharov av. ACS Chem Biol. 2017 Sep 15;12(9):2399-2407. doi: 10.1021/acschembio.7b00543. Epub 2017 Aug 24. ACS Chem Biol. 2017. PMID: 28836754 Free PMC article.

4

A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase.

Martinez NJ, Asawa RR, Cyr MG, Zakharov A, Urban DJ, Roth JS, Wallgren E, Klumpp-Thomas C, Coussens NP, Rai G, Yang SM, Hall MD, Marugan JJ, Simeonov A, Henderson MJ. Martinez NJ, et al. Sci Rep. 2018 Jun 21;8(1):9472. doi: 10.1038/s41598-018-27834-y. Sci Rep. 2018. PMID: 29930256 Free PMC article.

5

Novel Consensus Architecture To Improve Performance of Large-Scale Multitask Deep Learning QSAR Models.

Zakharov AV, Zhao T, Nguyen DT, Peryea T, Sheils T, Yasgar A, Huang R, Southall N, Simeonov A. Zakharov AV, et al. J Chem Inf Model. 2019 Nov 25;59(11):4613-4624. doi: 10.1021/acs.jcim.9b00526. Epub 2019 Oct 25. J Chem Inf Model. 2019. PMID: 31584270 Free PMC article.

6

A Comparative Study of Target Engagement Assays for HDAC1 Inhibitor Profiling.

Asawa RR, Zakharov A, Niehoff T, Chitsaz A, Jadhav A, Henderson MJ, Simeonov A, Martinez NJ. Asawa RR, et al. SLAS Discov. 2020 Mar;25(3):253-264. doi: 10.1177/2472555219883625. Epub 2019 Oct 29. SLAS Discov. 2020. PMID: 31662025 Free PMC article.

7

Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays.

Crowe A, Henderson MJ, Anderson J, Titus SA, Zakharov A, Simeonov A, Buist A, Delay C, Moechars D, Trojanowski JQ, Lee VM, Brunden KR. Crowe A, et al. J Biol Chem. 2020 Mar 20;295(12):4001-4013. doi: 10.1074/jbc.RA119.010532. Epub 2020 Feb 7. J Biol Chem. 2020. PMID: 32034092 Free PMC article.

8

A high-throughput screening platform for Polycystic Kidney Disease (PKD) drug repurposing utilizing murine and human ADPKD cells.

Asawa RR, Danchik C, Zakharov A, Chen Y, Voss T, Jadhav A, Wallace DP, Trott JF, Weiss RH, Simeonov A, Martinez NJ. Asawa RR, et al. Sci Rep. 2020 Mar 6;10(1):4203. doi: 10.1038/s41598-020-61082-3. Sci Rep. 2020. PMID: 32144367 Free PMC article.

9

Endonuclease FEN1 Coregulates ERα Activity and Provides a Novel Drug Interface in Tamoxifen-Resistant Breast Cancer.

Flach KD, Periyasamy M, Jadhav A, Dorjsuren D, Siefert JC, Hickey TE, Opdam M, Patel H, Canisius S, Wilson DM 3rd, Donaldson Collier M, Prekovic S, Nieuwland M, Kluin RJC, Zakharov AV, Wesseling J, Wessels LFA, Linn SC, Tilley WD, Simeonov A, Ali S, Zwart W. Flach KD, et al. Among authors: zakharov av. Cancer Res. 2020 May 15;80(10):1914-1926. doi: 10.1158/0008-5472.CAN-19-2207. Epub 2020 Mar 19. Cancer Res. 2020. PMID: 32193286

10

Optimization of High-Throughput Methyltransferase Assays for the Discovery of Small Molecule Inhibitors.

Dong G, Yasgar A, Peterson DL, Zakharov A, Talley D, Cheng KC, Jadhav A, Simeonov A, Huang R. Dong G, et al. ACS Comb Sci. 2020 Aug 10;22(8):422-432. doi: 10.1021/acscombsci.0c00077. Epub 2020 Jun 27. ACS Comb Sci. 2020. PMID: 32525297 Free PMC article.

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