Simeonov A - Search Results

1

Small Molecule Inhibitors of Activation-Induced Deaminase Decrease Class Switch Recombination in B Cells.

Alvarez-Gonzalez J, Yasgar A, Maul RW, Rieffer AE, Crawford DJ, Salamango DJ, Dorjsuren D, Zakharov AV, Jansen DJ, Rai G, Marugan J, Simeonov A, Harris RS, Kohli RM, Gearhart PJ. Alvarez-Gonzalez J, et al. Among authors: simeonov a. ACS Pharmacol Transl Sci. 2021 May 7;4(3):1214-1226. doi: 10.1021/acsptsci.1c00064. eCollection 2021 Jun 11. ACS Pharmacol Transl Sci. 2021. PMID: 34151211 Free PMC article.

2

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Inglese J, Auld DS, Jadhav A, Johnson RL, Simeonov A, Yasgar A, Zheng W, Austin CP. Inglese J, et al. Among authors: simeonov a. Proc Natl Acad Sci U S A. 2006 Aug 1;103(31):11473-8. doi: 10.1073/pnas.0604348103. Epub 2006 Jul 24. Proc Natl Acad Sci U S A. 2006. PMID: 16864780 Free PMC article.

3

A high-throughput 1,536-well luminescence assay for glutathione S-transferase activity.

Yasgar A, Shultz J, Zhou W, Wang H, Huang F, Murphy N, Abel EL, DiGiovanni J, Inglese J, Simeonov A. Yasgar A, et al. Among authors: simeonov a. Assay Drug Dev Technol. 2010 Apr;8(2):200-11. doi: 10.1089/adt.2009.0248. Assay Drug Dev Technol. 2010. PMID: 20085484 Free PMC article.

4

A strategy to discover inhibitors of Bacillus subtilis surfactin-type phosphopantetheinyl transferase.

Yasgar A, Foley TL, Jadhav A, Inglese J, Burkart MD, Simeonov A. Yasgar A, et al. Among authors: simeonov a. Mol Biosyst. 2010 Feb;6(2):365-75. doi: 10.1039/b913291k. Epub 2009 Oct 13. Mol Biosyst. 2010. PMID: 20094656 Free PMC article.

5

Preparation of FRET reporters to support chemical probe development.

Foley TL, Yasgar A, Garcia CJ, Jadhav A, Simeonov A, Burkart MD. Foley TL, et al. Among authors: simeonov a. Org Biomol Chem. 2010 Oct 21;8(20):4601-6. doi: 10.1039/c0ob00322k. Epub 2010 Aug 20. Org Biomol Chem. 2010. PMID: 20725690 Free PMC article.

6

Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1.

Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ. Rai G, et al. Among authors: simeonov a. J Med Chem. 2010 Oct 28;53(20):7392-404. doi: 10.1021/jm1008852. J Med Chem. 2010. PMID: 20866075 Free PMC article.

7

Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity.

Dorjsuren D, Kim D, Maloney DJ, Wilson DM 3rd, Simeonov A. Dorjsuren D, et al. Among authors: simeonov a. Nucleic Acids Res. 2011 Jan;39(2):e11. doi: 10.1093/nar/gkq1082. Epub 2010 Nov 9. Nucleic Acids Res. 2011. PMID: 21062821 Free PMC article.

8

Evaluation of quinazoline analogues as glucocerebrosidase inhibitors with chaperone activity.

Marugan JJ, Zheng W, Motabar O, Southall N, Goldin E, Westbroek W, Stubblefield BK, Sidransky E, Aungst RA, Lea WA, Simeonov A, Leister W, Austin CP. Marugan JJ, et al. Among authors: simeonov a. J Med Chem. 2011 Feb 24;54(4):1033-58. doi: 10.1021/jm1008902. Epub 2011 Jan 20. J Med Chem. 2011. PMID: 21250698 Free PMC article.

9

Discovery of potent and selective inhibitors of human platelet-type 12- lipoxygenase.

Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB 2nd, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, Holman TR. Kenyon V, et al. Among authors: simeonov a. J Med Chem. 2011 Aug 11;54(15):5485-97. doi: 10.1021/jm2005089. Epub 2011 Jul 8. J Med Chem. 2011. PMID: 21739938 Free PMC article.

10

Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors.

Rai G, Vyjayanti VN, Dorjsuren D, Simeonov A, Jadhav A, Wilson DM 3rd, Maloney DJ. Rai G, et al. Among authors: simeonov a. J Med Chem. 2012 Apr 12;55(7):3101-12. doi: 10.1021/jm201537d. Epub 2012 Mar 28. J Med Chem. 2012. PMID: 22455312 Free PMC article.

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