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A single cell characterisation of human embryogenesis identifies pluripotency transitions and putative anterior hypoblast centre.
Molè MA, Coorens THH, Shahbazi MN, Weberling A, Weatherbee BAT, Gantner CW, Sancho-Serra C, Richardson L, Drinkwater A, Syed N, Engley S, Snell P, Christie L, Elder K, Campbell A, Fishel S, Behjati S, Vento-Tormo R, Zernicka-Goetz M. Molè MA, et al. Among authors: christie l. Nat Commun. 2021 Jun 17;12(1):3679. doi: 10.1038/s41467-021-23758-w. Nat Commun. 2021. PMID: 34140473 Free PMC article.
Defining the three cell lineages of the human blastocyst by single-cell RNA-seq.
Blakeley P, Fogarty NM, del Valle I, Wamaitha SE, Hu TX, Elder K, Snell P, Christie L, Robson P, Niakan KK. Blakeley P, et al. Among authors: christie l. Development. 2015 Sep 15;142(18):3151-65. doi: 10.1242/dev.123547. Epub 2015 Aug 20. Development. 2015. PMID: 26293300 Free PMC article.
IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche.
Wamaitha SE, Grybel KJ, Alanis-Lobato G, Gerri C, Ogushi S, McCarthy A, Mahadevaiah SK, Healy L, Lea RA, Molina-Arcas M, Devito LG, Elder K, Snell P, Christie L, Downward J, Turner JMA, Niakan KK. Wamaitha SE, et al. Among authors: christie l. Nat Commun. 2020 Feb 7;11(1):764. doi: 10.1038/s41467-020-14629-x. Nat Commun. 2020. PMID: 32034154 Free PMC article.
Initiation of a conserved trophectoderm program in human, cow and mouse embryos.
Gerri C, McCarthy A, Alanis-Lobato G, Demtschenko A, Bruneau A, Loubersac S, Fogarty NME, Hampshire D, Elder K, Snell P, Christie L, David L, Van de Velde H, Fouladi-Nashta AA, Niakan KK. Gerri C, et al. Among authors: christie l. Nature. 2020 Nov;587(7834):443-447. doi: 10.1038/s41586-020-2759-x. Epub 2020 Sep 23. Nature. 2020. PMID: 32968278 Free PMC article.
KLF17 promotes human naïve pluripotency but is not required for its establishment.
Lea RA, McCarthy A, Boeing S, Fallesen T, Elder K, Snell P, Christie L, Adkins S, Shaikly V, Taranissi M, Niakan KK. Lea RA, et al. Among authors: christie l. Development. 2021 Nov 15;148(22):dev199378. doi: 10.1242/dev.199378. Epub 2021 Nov 15. Development. 2021. PMID: 34661235 Free PMC article.
A conserved role of the Hippo signalling pathway in initiation of the first lineage specification event across mammals.
Gerri C, McCarthy A, Mei Scott G, Regin M, Stamatiadis P, Brumm S, Simon CS, Lee J, Montesinos C, Hassitt C, Hockenhull S, Hampshire D, Elder K, Snell P, Christie L, Fouladi-Nashta AA, Van de Velde H, Niakan KK. Gerri C, et al. Among authors: christie l. Development. 2023 Apr 15;150(8):dev201112. doi: 10.1242/dev.201112. Epub 2023 Apr 20. Development. 2023. PMID: 36971487 Free PMC article.
Distinct pathways drive anterior hypoblast specification in the implanting human embryo.
Weatherbee BAT, Weberling A, Gantner CW, Iwamoto-Stohl LK, Barnikel Z, Barrie A, Campbell A, Cunningham P, Drezet C, Efstathiou P, Fishel S, Vindel SG, Lockwood M, Oakley R, Pretty C, Chowdhury N, Richardson L, Mania A, Weavers L, Christie L, Elder K, Snell P, Zernicka-Goetz M. Weatherbee BAT, et al. Among authors: christie l. Nat Cell Biol. 2024 Mar;26(3):353-365. doi: 10.1038/s41556-024-01367-1. Epub 2024 Mar 5. Nat Cell Biol. 2024. PMID: 38443567 Free PMC article.
Transcription factor-based transdifferentiation of human embryonic to trophoblast stem cells.
Balestrini PA, Abdelbaki A, McCarthy A, Devito L, Senner CE, Chen AE, Munusamy P, Blakeley P, Elder K, Snell P, Christie L, Serhal P, Odia RA, Sangrithi M, Niakan KK, Fogarty NME. Balestrini PA, et al. Among authors: christie l. Development. 2024 Sep 1;151(17):dev202778. doi: 10.1242/dev.202778. Epub 2024 Sep 10. Development. 2024. PMID: 39250534 Free PMC article.
315 results