Deng D - Search Results

1

Discovery, Optimization, and Evaluation of Quinazolinone Derivatives with Novel Linkers as Orally Efficacious Phosphoinositide-3-Kinase Delta Inhibitors for Treatment of Inflammatory Diseases.

Liu K, Li D, Zheng W, Shi M, Chen Y, Tang M, Yang T, Zhao M, Deng D, Zhang C, Liu J, Yuan X, Yang Z, Chen L. Liu K, et al. Among authors: deng d. J Med Chem. 2021 Jul 8;64(13):8951-8970. doi: 10.1021/acs.jmedchem.1c00004. Epub 2021 Jun 17. J Med Chem. 2021. PMID: 34138567

2

[Review on experimental studies of Chinese drugs in antagonizing bone marrow inhibition caused by chemicals].

Yang T, Deng D. Yang T, et al. Among authors: deng d. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999 Aug;19(8):506-8. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1999. PMID: 11783234 Review. Chinese. No abstract available.

3

Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis.

Deng D, Pei H, Lan T, Zhu J, Tang M, Xue L, Yang Z, Zheng S, Ye H, Chen L. Deng D, et al. Eur J Med Chem. 2020 Jan 1;185:111790. doi: 10.1016/j.ejmech.2019.111790. Epub 2019 Oct 19. Eur J Med Chem. 2020. PMID: 31699535

4

Design, synthesis and discovery of 2(1H)-quinolone derivatives for the treatment of pulmonary fibrosis through inhibition of TGF-β/smad dependent and independent pathway.

Xue L, Deng D, Zheng S, Tang M, Yang Z, Pei H, Chen Y, Yang T, Liu K, Ye H, Chen L. Xue L, et al. Among authors: deng d. Eur J Med Chem. 2020 Jul 1;197:112259. doi: 10.1016/j.ejmech.2020.112259. Epub 2020 Apr 6. Eur J Med Chem. 2020. PMID: 32334267

5

Synthesis and evaluation of new compounds bearing 3-(4-aminopiperidin-1-yl)methyl magnolol scaffold as anticancer agents for the treatment of non-small cell lung cancer via targeting autophagy.

Zhao M, Zheng YH, Zhao QY, Zheng W, Yang JH, Pei HY, Liu L, Liu KJ, Xue LL, Deng DX, Wang L, Ma X, Fu SH, Peng AH, Tang MH, Luo YZ, Ye HY, Chen LJ. Zhao M, et al. Eur J Med Chem. 2021 Jan 1;209:112922. doi: 10.1016/j.ejmech.2020.112922. Epub 2020 Oct 10. Eur J Med Chem. 2021. PMID: 33069436

6

Discovery of 3-(4-(2-((1H-Indol-5-yl)amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-1-yl)propanenitrile Derivatives as Selective TYK2 Inhibitors for the Treatment of Inflammatory Bowel Disease.

Zhang C, Qi W, Li Y, Tang M, Yang T, Liu K, Chen Y, Deng D, Xiang M, Chen L. Zhang C, et al. Among authors: deng d. J Med Chem. 2021 Feb 25;64(4):1966-1988. doi: 10.1021/acs.jmedchem.0c01468. Epub 2021 Feb 16. J Med Chem. 2021. PMID: 33593051

7

Degrading FLT3-ITD protein by proteolysis targeting chimera (PROTAC).

Chen Y, Yuan X, Tang M, Shi M, Yang T, Liu K, Deng D, Chen L. Chen Y, et al. Among authors: deng d. Bioorg Chem. 2022 Feb;119:105508. doi: 10.1016/j.bioorg.2021.105508. Epub 2021 Nov 29. Bioorg Chem. 2022. PMID: 34959180

8

Synthesis and biological evaluation of 6-(pyrimidin-4-yl)-1H-pyrazolo[4,3-b]pyridine derivatives as novel dual FLT3/CDK4 inhibitors.

Li X, Yang T, Hu M, Yang Y, Tang M, Deng D, Liu K, Fu S, Tan Y, Wang H, Chen Y, Zhang C, Guo Y, Peng B, Si W, Yang Z, Chen L. Li X, et al. Among authors: deng d. Bioorg Chem. 2022 Apr;121:105669. doi: 10.1016/j.bioorg.2022.105669. Epub 2022 Feb 11. Bioorg Chem. 2022. PMID: 35180490

9

Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein Kinase 2 (RIPK2) Inhibitors for the Treatment of Inflammatory Bowel Diseases (IBDs).

Yuan X, Chen Y, Tang M, Wei Y, Shi M, Yang Y, Zhou Y, Yang T, Liu J, Liu K, Deng D, Zhang C, Chen L. Yuan X, et al. Among authors: deng d. J Med Chem. 2022 Jul 14;65(13):9312-9327. doi: 10.1021/acs.jmedchem.2c00604. Epub 2022 Jun 16. J Med Chem. 2022. PMID: 35709396

10

Discovery, Optimization, and Evaluation of Potent and Selective PI3Kδ-γ Dual Inhibitors for the Treatment of B-cell Malignancies.

Liu K, Zheng W, Chen Y, Tang M, Li D, Deng D, Yang T, Zhang C, Liu J, Yuan X, Shi M, Li X, Guo Y, Zhou Y, Zhao M, Chen L. Liu K, et al. Among authors: deng d. J Med Chem. 2022 Jul 28;65(14):9893-9917. doi: 10.1021/acs.jmedchem.2c00568. Epub 2022 Jul 13. J Med Chem. 2022. PMID: 35831917

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