Sarkar S - Search Results

1

CD38-specific Chimeric Antigen Receptor Expressing Natural Killer KHYG-1 Cells: A Proof of Concept for an "Off the Shelf" Therapy for Multiple Myeloma.

Stikvoort A, van der Schans J, Sarkar S, Poels R, Ruiter R, Naik J, Yuan H, de Bruijn JD, van de Donk NWCJ, Zweegman S, Themeli M, Groen R, O'Dwyer M, Mutis T. Stikvoort A, et al. Among authors: sarkar s. Hemasphere. 2021 Jun 12;5(7):e596. doi: 10.1097/HS9.0000000000000596. eCollection 2021 Jul. Hemasphere. 2021. PMID: 34131635 Free PMC article.

2

Optimal selection of natural killer cells to kill myeloma: the role of HLA-E and NKG2A.

Sarkar S, van Gelder M, Noort W, Xu Y, Rouschop KM, Groen R, Schouten HC, Tilanus MG, Germeraad WT, Martens AC, Bos GM, Wieten L. Sarkar S, et al. Cancer Immunol Immunother. 2015 Aug;64(8):951-63. doi: 10.1007/s00262-015-1694-4. Epub 2015 Apr 29. Cancer Immunol Immunother. 2015. PMID: 25920521 Free PMC article.

3

The CD38^low natural killer cell line KHYG1 transiently expressing CD16^F158V in combination with daratumumab targets multiple myeloma cells with minimal effector NK cell fratricide.

Sarkar S, Chauhan SKS, Daly J, Natoni A, Fairfield H, Henderson R, Nolan E, Swan D, Hu J, Reagan MR, O'Dwyer M. Sarkar S, et al. Cancer Immunol Immunother. 2020 Mar;69(3):421-434. doi: 10.1007/s00262-019-02477-8. Epub 2020 Jan 9. Cancer Immunol Immunother. 2020. PMID: 31919623 Free PMC article.

4

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector cell fratricide.

Gurney M, Stikvoort A, Nolan E, Kirkham-McCarthy L, Khoruzhenko S, Shivakumar R, Zweegman S, Van de Donk NWCJ, Mutis T, Szegezdi E, Sarkar S, O'Dwyer M. Gurney M, et al. Among authors: sarkar s. Haematologica. 2022 Feb 1;107(2):437-445. doi: 10.3324/haematol.2020.271908. Haematologica. 2022. PMID: 33375774 Free PMC article.

5

Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell-mediated tumor responses.

Daly J, Sarkar S, Natoni A, Stark JC, Riley NM, Bertozzi CR, Carlsten M, O'Dwyer ME. Daly J, et al. Among authors: sarkar s. Blood Adv. 2022 Jun 14;6(11):3352-3366. doi: 10.1182/bloodadvances.2021006805. Blood Adv. 2022. PMID: 35294519 Free PMC article.

6

NK cell line modified to express a potent, DR5 specific variant of TRAIL, show enhanced cytotoxicity in ovarian cancer models.

Sheedy AM, Burduli N, Prakash A, Gurney M, Hanley S, Prendeville H, Sarkar S, O'Dwyer J, O'Dwyer M, Dolan EB. Sheedy AM, et al. Among authors: sarkar s. Heliyon. 2024 Jul 19;10(15):e34976. doi: 10.1016/j.heliyon.2024.e34976. eCollection 2024 Aug 15. Heliyon. 2024. PMID: 39170449 Free PMC article.

7

Hypoxia induced impairment of NK cell cytotoxicity against multiple myeloma can be overcome by IL-2 activation of the NK cells.

Sarkar S, Germeraad WT, Rouschop KM, Steeghs EM, van Gelder M, Bos GM, Wieten L. Sarkar S, et al. PLoS One. 2013 May 28;8(5):e64835. doi: 10.1371/journal.pone.0064835. Print 2013. PLoS One. 2013. PMID: 23724099 Free PMC article.

8

NKG2A Expression Is Not per se Detrimental for the Anti-Multiple Myeloma Activity of Activated Natural Killer Cells in an In Vitro System Mimicking the Tumor Microenvironment.

Mahaweni NM, Ehlers FAI, Sarkar S, Janssen JWH, Tilanus MGJ, Bos GMJ, Wieten L. Mahaweni NM, et al. Among authors: sarkar s. Front Immunol. 2018 Jun 22;9:1415. doi: 10.3389/fimmu.2018.01415. eCollection 2018. Front Immunol. 2018. PMID: 29988376 Free PMC article.

9

Ascorbic acid promotes proliferation of natural killer cell populations in culture systems applicable for natural killer cell therapy.

Huijskens MJ, Walczak M, Sarkar S, Atrafi F, Senden-Gijsbers BL, Tilanus MG, Bos GM, Wieten L, Germeraad WT. Huijskens MJ, et al. Among authors: sarkar s. Cytotherapy. 2015 May;17(5):613-20. doi: 10.1016/j.jcyt.2015.01.004. Epub 2015 Mar 5. Cytotherapy. 2015. PMID: 25747742

10

Clinical Manifestations.

Kota K, Hundal J, Sotelo V, Dawson A, Sarkar S, Hu WT. Kota K, et al. Among authors: sarkar s. Alzheimers Dement. 2024 Dec;20 Suppl 3:e088313. doi: 10.1002/alz.088313. Alzheimers Dement. 2024. PMID: 39750298

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