Boshoff HIM - Search Results

1

Reinvestigation of the structure-activity relationships of isoniazid.

Hegde P, Boshoff HIM, Rusman Y, Aragaw WW, Salomon CE, Dick T, Aldrich CC. Hegde P, et al. Among authors: boshoff him. Tuberculosis (Edinb). 2021 Jul;129:102100. doi: 10.1016/j.tube.2021.102100. Epub 2021 Jun 5. Tuberculosis (Edinb). 2021. PMID: 34116482 Free PMC article.

2

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis.

Manjunatha UH, Boshoff H, Dowd CS, Zhang L, Albert TJ, Norton JE, Daniels L, Dick T, Pang SS, Barry CE 3rd. Manjunatha UH, et al. Proc Natl Acad Sci U S A. 2006 Jan 10;103(2):431-6. doi: 10.1073/pnas.0508392103. Epub 2005 Dec 30. Proc Natl Acad Sci U S A. 2006. PMID: 16387854 Free PMC article.

3

Rationally designed nucleoside antibiotics that inhibit siderophore biosynthesis of Mycobacterium tuberculosis.

Somu RV, Boshoff H, Qiao C, Bennett EM, Barry CE 3rd, Aldrich CC. Somu RV, et al. J Med Chem. 2006 Jan 12;49(1):31-4. doi: 10.1021/jm051060o. J Med Chem. 2006. PMID: 16392788

4

Design, synthesis, and biological evaluation of beta-ketosulfonamide adenylation inhibitors as potential antitubercular agents.

Vannada J, Bennett EM, Wilson DJ, Boshoff HI, Barry CE 3rd, Aldrich CC. Vannada J, et al. Org Lett. 2006 Oct 12;8(21):4707-10. doi: 10.1021/ol0617289. Org Lett. 2006. PMID: 17020283 Free PMC article.

5

Antitubercular nucleosides that inhibit siderophore biosynthesis: SAR of the glycosyl domain.

Somu RV, Wilson DJ, Bennett EM, Boshoff HI, Celia L, Beck BJ, Barry CE 3rd, Aldrich CC. Somu RV, et al. J Med Chem. 2006 Dec 28;49(26):7623-35. doi: 10.1021/jm061068d. J Med Chem. 2006. PMID: 17181146 Free PMC article.

6

5'-O-[(N-acyl)sulfamoyl]adenosines as antitubercular agents that inhibit MbtA: an adenylation enzyme required for siderophore biosynthesis of the mycobactins.

Qiao C, Gupte A, Boshoff HI, Wilson DJ, Bennett EM, Somu RV, Barry CE 3rd, Aldrich CC. Qiao C, et al. J Med Chem. 2007 Nov 29;50(24):6080-94. doi: 10.1021/jm070905o. Epub 2007 Oct 30. J Med Chem. 2007. PMID: 17967002 Free PMC article.

7

Inhibition of siderophore biosynthesis in Mycobacterium tuberculosis with nucleoside bisubstrate analogues: structure-activity relationships of the nucleobase domain of 5'-O-[N-(salicyl)sulfamoyl]adenosine.

Neres J, Labello NP, Somu RV, Boshoff HI, Wilson DJ, Vannada J, Chen L, Barry CE 3rd, Bennett EM, Aldrich CC. Neres J, et al. J Med Chem. 2008 Sep 11;51(17):5349-70. doi: 10.1021/jm800567v. Epub 2008 Aug 9. J Med Chem. 2008. PMID: 18690677 Free PMC article.

8

Inhibition of siderophore biosynthesis by 2-triazole substituted analogues of 5'-O-[N-(salicyl)sulfamoyl]adenosine: antibacterial nucleosides effective against Mycobacterium tuberculosis.

Gupte A, Boshoff HI, Wilson DJ, Neres J, Labello NP, Somu RV, Xing C, Barry CE, Aldrich CC. Gupte A, et al. J Med Chem. 2008 Dec 11;51(23):7495-507. doi: 10.1021/jm8008037. J Med Chem. 2008. PMID: 19053762 Free PMC article.

9

Structure-activity relationships of antitubercular nitroimidazoles. 1. Structural features associated with aerobic and anaerobic activities of 4- and 5-nitroimidazoles.

Kim P, Zhang L, Manjunatha UH, Singh R, Patel S, Jiricek J, Keller TH, Boshoff HI, Barry CE 3rd, Dowd CS. Kim P, et al. J Med Chem. 2009 Mar 12;52(5):1317-28. doi: 10.1021/jm801246z. J Med Chem. 2009. PMID: 19209889 Free PMC article.

10

Structure-activity relationships of antitubercular nitroimidazoles. 2. Determinants of aerobic activity and quantitative structure-activity relationships.

Kim P, Kang S, Boshoff HI, Jiricek J, Collins M, Singh R, Manjunatha UH, Niyomrattanakit P, Zhang L, Goodwin M, Dick T, Keller TH, Dowd CS, Barry CE 3rd. Kim P, et al. J Med Chem. 2009 Mar 12;52(5):1329-44. doi: 10.1021/jm801374t. J Med Chem. 2009. PMID: 19209893 Free PMC article.

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