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Page 1
Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.
Difilippantonio S, Celeste A, Fernandez-Capetillo O, Chen HT, Reina San Martin B, Van Laethem F, Yang YP, Petukhova GV, Eckhaus M, Feigenbaum L, Manova K, Kruhlak M, Camerini-Otero RD, Sharan S, Nussenzweig M, Nussenzweig A. Difilippantonio S, et al. Nat Cell Biol. 2005 Jul;7(7):675-85. doi: 10.1038/ncb1270. Epub 2005 Jun 19. Nat Cell Biol. 2005. PMID: 15965469
RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females.
Kuznetsov S, Pellegrini M, Shuda K, Fernandez-Capetillo O, Liu Y, Martin BK, Burkett S, Southon E, Pati D, Tessarollo L, West SC, Donovan PJ, Nussenzweig A, Sharan SK. Kuznetsov S, et al. Among authors: sharan sk. J Cell Biol. 2007 Feb 26;176(5):581-92. doi: 10.1083/jcb.200608130. Epub 2007 Feb 20. J Cell Biol. 2007. PMID: 17312021 Free PMC article.
Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155.
Chang S, Wang RH, Akagi K, Kim KA, Martin BK, Cavallone L; Kathleen Cuningham Foundation Consortium for Research into Familial Breast Cancer (kConFab); Haines DC, Basik M, Mai P, Poggi E, Isaacs C, Looi LM, Mun KS, Greene MH, Byers SW, Teo SH, Deng CX, Sharan SK. Chang S, et al. Among authors: sharan sk. Nat Med. 2011 Sep 25;17(10):1275-82. doi: 10.1038/nm.2459. Nat Med. 2011. PMID: 21946536 Free PMC article.
Functional evaluation of BRCA2 variants mapping to the PALB2-binding and C-terminal DNA-binding domains using a mouse ES cell-based assay.
Biswas K, Das R, Eggington JM, Qiao H, North SL, Stauffer S, Burkett SS, Martin BK, Southon E, Sizemore SC, Pruss D, Bowles KR, Roa BB, Hunter N, Tessarollo L, Wenstrup RJ, Byrd RA, Sharan SK. Biswas K, et al. Among authors: sharan sk. Hum Mol Genet. 2012 Sep 15;21(18):3993-4006. doi: 10.1093/hmg/dds222. Epub 2012 Jun 7. Hum Mol Genet. 2012. PMID: 22678057 Free PMC article.
BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation.
Thirthagiri E, Klarmann KD, Shukla AK, Southon E, Biswas K, Martin BK, North SL, Magidson V, Burkett S, Haines DC, Noer K, Matthai R, Tessarollo L, Loncarek J, Keller JR, Sharan SK. Thirthagiri E, et al. Among authors: sharan sk. Hum Mol Genet. 2016 May 15;25(10):1934-1945. doi: 10.1093/hmg/ddw066. Epub 2016 Feb 26. Hum Mol Genet. 2016. PMID: 26920070 Free PMC article.
Replication fork stability confers chemoresistance in BRCA-deficient cells.
Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, Lee JE, Wong N, Lafarga V, Calvo JA, Panzarino NJ, John S, Day A, Crespo AV, Shen B, Starnes LM, de Ruiter JR, Daniel JA, Konstantinopoulos PA, Cortez D, Cantor SB, Fernandez-Capetillo O, Ge K, Jonkers J, Rottenberg S, Sharan SK, Nussenzweig A. Ray Chaudhuri A, et al. Among authors: sharan sk. Nature. 2016 Jul 21;535(7612):382-7. doi: 10.1038/nature18325. Nature. 2016. PMID: 27443740 Free PMC article.
Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2.
Hartford SA, Chittela R, Ding X, Vyas A, Martin B, Burkett S, Haines DC, Southon E, Tessarollo L, Sharan SK. Hartford SA, et al. Among authors: sharan sk. PLoS Genet. 2016 Aug 4;12(8):e1006236. doi: 10.1371/journal.pgen.1006236. eCollection 2016 Aug. PLoS Genet. 2016. PMID: 27490902 Free PMC article.
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies.
Ding X, Ray Chaudhuri A, Callen E, Pang Y, Biswas K, Klarmann KD, Martin BK, Burkett S, Cleveland L, Stauffer S, Sullivan T, Dewan A, Marks H, Tubbs AT, Wong N, Buehler E, Akagi K, Martin SE, Keller JR, Nussenzweig A, Sharan SK. Ding X, et al. Among authors: sharan sk. Nat Commun. 2016 Aug 8;7:12425. doi: 10.1038/ncomms12425. Nat Commun. 2016. PMID: 27498558 Free PMC article.
100 results