Muegge K - Search Results

1

The epigenetic regulator LSH maintains fork protection and genomic stability via MacroH2A deposition and RAD51 filament formation.

Xu X, Ni K, He Y, Ren J, Sun C, Liu Y, Aladjem MI, Burkett S, Finney R, Ding X, Sharan SK, Muegge K. Xu X, et al. Among authors: muegge k. Nat Commun. 2021 Jun 10;12(1):3520. doi: 10.1038/s41467-021-23809-2. Nat Commun. 2021. PMID: 34112784 Free PMC article.

2

Lsh, a modulator of CpG methylation, is crucial for normal histone methylation.

Yan Q, Huang J, Fan T, Zhu H, Muegge K. Yan Q, et al. Among authors: muegge k. EMBO J. 2003 Oct 1;22(19):5154-62. doi: 10.1093/emboj/cdg493. EMBO J. 2003. PMID: 14517253 Free PMC article.

3

Lsh, a guardian of heterochromatin at repeat elements.

Muegge K. Muegge K. Biochem Cell Biol. 2005 Aug;83(4):548-54. doi: 10.1139/o05-119. Biochem Cell Biol. 2005. PMID: 16094458 Review.

4

CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity.

Yu W, Briones V, Lister R, McIntosh C, Han Y, Lee EY, Ren J, Terashima M, Leighty RM, Ecker JR, Muegge K. Yu W, et al. Among authors: muegge k. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5890-5. doi: 10.1073/pnas.1320945111. Epub 2014 Apr 7. Proc Natl Acad Sci U S A. 2014. PMID: 24711395 Free PMC article.

5

Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways.

Yu W, McIntosh C, Lister R, Zhu I, Han Y, Ren J, Landsman D, Lee E, Briones V, Terashima M, Leighty R, Ecker JR, Muegge K. Yu W, et al. Among authors: muegge k. Genome Res. 2014 Oct;24(10):1613-23. doi: 10.1101/gr.172015.114. Epub 2014 Aug 28. Genome Res. 2014. PMID: 25170028 Free PMC article.

6

The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences.

Ren J, Briones V, Barbour S, Yu W, Han Y, Terashima M, Muegge K. Ren J, et al. Among authors: muegge k. Nucleic Acids Res. 2015 Feb 18;43(3):1444-55. doi: 10.1093/nar/gku1371. Epub 2015 Jan 10. Nucleic Acids Res. 2015. PMID: 25578963 Free PMC article.

7

Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression.

Terashima M, Barbour S, Ren J, Yu W, Han Y, Muegge K. Terashima M, et al. Among authors: muegge k. Epigenetics. 2015;10(9):861-71. doi: 10.1080/15592294.2015.1075691. Epigenetics. 2015. PMID: 26252449 Free PMC article.

8

Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells.

Han Y, Ren J, Lee E, Xu X, Yu W, Muegge K. Han Y, et al. Among authors: muegge k. Sci Rep. 2017 Apr 25;7(1):1136. doi: 10.1038/s41598-017-00804-6. Sci Rep. 2017. PMID: 28442710 Free PMC article.

9

Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.

Ren J, Hathaway NA, Crabtree GR, Muegge K. Ren J, et al. Among authors: muegge k. Epigenetics. 2018;13(2):173-181. doi: 10.1080/15592294.2017.1338234. Epub 2018 Feb 6. Epigenetics. 2018. PMID: 28621576 Free PMC article.

10

The chromatin remodeling protein Lsh alters nucleosome occupancy at putative enhancers and modulates binding of lineage specific transcription factors.

Ren J, Finney R, Ni K, Cam M, Muegge K. Ren J, et al. Among authors: muegge k. Epigenetics. 2019 Mar;14(3):277-293. doi: 10.1080/15592294.2019.1582275. Epub 2019 Mar 12. Epigenetics. 2019. PMID: 30861354 Free PMC article.

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