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Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury.
Widjaja AA, Dong J, Adami E, Viswanathan S, Ng B, Pakkiri LS, Chothani SP, Singh BK, Lim WW, Zhou J, Shekeran SG, Tan J, Lim SY, Goh J, Wang M, Holgate R, Hearn A, Felkin LE, Yen PM, Dear JW, Drum CL, Schafer S, Cook SA. Widjaja AA, et al. Among authors: hearn a. Sci Transl Med. 2021 Jun 9;13(597):eaba8146. doi: 10.1126/scitranslmed.aba8146. Sci Transl Med. 2021. PMID: 34108253
Selective blood-brain barrier permeabilization of brain metastases by a type 1 receptor-selective tumor necrosis factor mutein.
Munoz Pinto MF, Campbell SJ, Simoglou Karali C, Johanssen VA, Bristow C, Cheng VWT, Zarghami N, Larkin JR, Pannell M, Hearn A, Chui C, Brinquis Nunez B, Bokma E, Holgate R, Anthony DC, Sibson NR. Munoz Pinto MF, et al. Among authors: hearn a. Neuro Oncol. 2022 Jan 5;24(1):52-63. doi: 10.1093/neuonc/noab177. Neuro Oncol. 2022. PMID: 34297105 Free PMC article.
Blocking FcRn in humans reduces circulating IgG levels and inhibits IgG immune complex-mediated immune responses.
Blumberg LJ, Humphries JE, Jones SD, Pearce LB, Holgate R, Hearn A, Cheung J, Mahmood A, Del Tito B, Graydon JS, Stolz LE, Bitonti A, Purohit S, de Graaf D, Kacena K, Andersen JT, Christianson GJ, Roopenian DC, Hubbard JJ, Gandhi AK, Lasseter K, Pyzik M, Blumberg RS. Blumberg LJ, et al. Among authors: hearn a. Sci Adv. 2019 Dec 18;5(12):eaax9586. doi: 10.1126/sciadv.aax9586. eCollection 2019 Dec. Sci Adv. 2019. PMID: 31897428 Free PMC article. Clinical Trial.
Climate-driven global redistribution of an ocean giant predicts increased threat from shipping.
Womersley FC, Sousa LL, Humphries NE, Abrantes K, Araujo G, Bach SS, Barnett A, Berumen ML, Lion SB, Braun CD, Clingham E, Cochran JEM, de la Parra R, Diamant S, Dove ADM, Duarte CM, Dudgeon CL, Erdmann MV, Espinoza E, Ferreira LC, Fitzpatrick R, Cano JG, Green JR, Guzman HM, Hardenstine R, Hasan A, Hazin FHV, Hearn AR, Hueter RE, Jaidah MY, Labaja J, Ladino F, Macena BCL, Meekan MG, Morris JJ Jr, Norman BM, Peñaherrera-Palma CR, Pierce SJ, Quintero LM, Ramírez-Macías D, Reynolds SD, Robinson DP, Rohner CA, Rowat DRL, Sequeira AMM, Sheaves M, Shivji MS, Sianipar AB, Skomal GB, Soler G, Syakurachman I, Thorrold SR, Thums M, Tyminski JP, Webb DH, Wetherbee BM, Queiroz N, Sims DW. Womersley FC, et al. Among authors: hearn ar. Nat Clim Chang. 2024;14(12):1282-1291. doi: 10.1038/s41558-024-02129-5. Epub 2024 Oct 7. Nat Clim Chang. 2024. PMID: 39650805 Free PMC article.
137 results