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Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.
Sagar S, Singh S, Mallareddy JR, Sonawane YA, Napoleon JV, Rana S, Contreras JI, Rajesh C, Ezell EL, Kizhake S, Garrison JC, Radhakrishnan P, Natarajan A. Sagar S, et al. Among authors: mallareddy jr. Eur J Med Chem. 2021 Oct 15;222:113579. doi: 10.1016/j.ejmech.2021.113579. Epub 2021 May 30. Eur J Med Chem. 2021. PMID: 34098465 Free PMC article.
Aminopyrazole based CDK9 PROTAC sensitizes pancreatic cancer cells to venetoclax.
King HM, Rana S, Kubica SP, Mallareddy JR, Kizhake S, Ezell EL, Zahid M, Naldrett MJ, Alvarez S, Law HC, Woods NT, Natarajan A. King HM, et al. Among authors: mallareddy jr. Bioorg Med Chem Lett. 2021 Jul 1;43:128061. doi: 10.1016/j.bmcl.2021.128061. Epub 2021 Apr 23. Bioorg Med Chem Lett. 2021. PMID: 33895280 Free PMC article.
Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.
Napoleon JV, Sagar S, Kubica SP, Boghean L, Kour S, King HM, Sonawane YA, Crawford AJ, Gautam N, Kizhake S, Bialk PA, Kmiec E, Mallareddy JR, Patil PP, Rana S, Singh S, Prahlad J, Grandgenett PM, Borgstahl GEO, Ghosal G, Alnouti Y, Hollingsworth MA, Radhakrishnan P, Natarajan A. Napoleon JV, et al. Among authors: mallareddy jr. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2115071119. doi: 10.1073/pnas.2115071119. Epub 2022 Apr 27. Proc Natl Acad Sci U S A. 2022. PMID: 35476515 Free PMC article.
Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells.
Kour S, Rana S, Kubica SP, Kizhake S, Ahmad M, Muñoz-Trujillo C, Klinkebiel D, Singh S, Mallareddy JR, Chandra S, Woods NT, Karpf AR, Natarajan A. Kour S, et al. Among authors: mallareddy jr. J Biol Chem. 2022 May;298(5):101890. doi: 10.1016/j.jbc.2022.101890. Epub 2022 Apr 1. J Biol Chem. 2022. PMID: 35378132 Free PMC article.
Systemic Administration of a Brain Permeable Cdk5 Inhibitor Alters Neurobehavior.
Umfress A, Singh S, Ryan KJ, Chakraborti A, Plattner F, Sonawane Y, Mallareddy JR, Acosta EP, Natarajan A, Bibb JA. Umfress A, et al. Among authors: mallareddy jr. Front Pharmacol. 2022 May 12;13:863762. doi: 10.3389/fphar.2022.863762. eCollection 2022. Front Pharmacol. 2022. PMID: 35645825 Free PMC article.
30 results