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Deletion of newly described pro-survival molecule Pellino-1 increases oxidative stress, downregulates cIAP2/NF-κB cell survival pathway, reduces angiogenic response, and thereby aggravates tissue function in mouse ischemic models.
Selvaraju V, Thirunavukkarasu M, Joshi M, Oriowo B, Shaikh IA, Rishi MT, Tapias L, Coca-Soliz V, Saad I, Campbell J, Pradeep SR, Swaminathan S, Yee SP, McFadden DW, Alexander Palesty J, Maulik N. Selvaraju V, et al. Among authors: pradeep sr. Basic Res Cardiol. 2020 Jun 14;115(4):45. doi: 10.1007/s00395-020-0804-4. Basic Res Cardiol. 2020. PMID: 32537701
Gene therapy with Pellino-1 improves perfusion and decreases tissue loss in Flk-1 heterozygous mice but fails in MAPKAP Kinase-2 knockout murine hind limb ischemia model.
Thirunavukkarasu M, Pradeep SR, Ukani G, Abunnaja S, Youssef M, Accorsi D, Swaminathan S, Lim ST, Parker V, Campbell J, Tipu Rishi M, Palesty JA, Maulik N. Thirunavukkarasu M, et al. Among authors: pradeep sr. Microvasc Res. 2022 May;141:104311. doi: 10.1016/j.mvr.2022.104311. Epub 2022 Jan 7. Microvasc Res. 2022. PMID: 34999110 Free PMC article.
Driving adult tissue repair via re-engagement of a pathway required for fetal healing.
Ghatak S, Khanna S, Roy S, Thirunavukkarasu M, Pradeep SR, Wulff BC, El Masry MS, Sharma A, Palakurti R, Ghosh N, Xuan Y, Wilgus TA, Maulik N, Yoder MC, Sen CK. Ghatak S, et al. Among authors: pradeep sr. Mol Ther. 2023 Feb 1;31(2):454-470. doi: 10.1016/j.ymthe.2022.09.002. Epub 2022 Sep 15. Mol Ther. 2023. PMID: 36114673 Free PMC article.
Novel approaches to determine the functional role of cardiomyocyte specific E3 ligase, Pellino-1 following myocardial infarction.
Pradeep SR, Thirunavukkarasu M, Accorsi D, Swaminathan S, Lim ST, Cernuda B, Kemerley A, Hubbard J, Campbell J, Wilson RL, Coca-Soliz V, Tapias L, Selvaraju V, Jellison ER, Yee SP, Palesty JA, Maulik N. Pradeep SR, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166899. doi: 10.1016/j.bbadis.2023.166899. Epub 2023 Sep 29. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37778482 Free article.
17 results