Sasahara K - Search Results

1

Feature importance of machine learning prediction models shows structurally active part and important physicochemical features in drug design.

Sasahara K, Shibata M, Sasabe H, Suzuki T, Takeuchi K, Umehara K, Kashiyama E. Sasahara K, et al. Drug Metab Pharmacokinet. 2021 Aug;39:100401. doi: 10.1016/j.dmpk.2021.100401. Epub 2021 May 3. Drug Metab Pharmacokinet. 2021. PMID: 34089983

2

Predicting drug metabolism and pharmacokinetics features of in-house compounds by a hybrid machine-learning model.

Sasahara K, Shibata M, Sasabe H, Suzuki T, Takeuchi K, Umehara K, Kashiyama E. Sasahara K, et al. Drug Metab Pharmacokinet. 2021 Aug;39:100395. doi: 10.1016/j.dmpk.2021.100395. Epub 2021 Apr 20. Drug Metab Pharmacokinet. 2021. PMID: 33991751

3

Pharmacokinetics and Metabolism of Delamanid, a Novel Anti-Tuberculosis Drug, in Animals and Humans: Importance of Albumin Metabolism In Vivo.

Sasahara K, Shimokawa Y, Hirao Y, Koyama N, Kitano K, Shibata M, Umehara K. Sasahara K, et al. Drug Metab Dispos. 2015 Aug;43(8):1267-76. doi: 10.1124/dmd.115.064527. Epub 2015 Jun 8. Drug Metab Dispos. 2015. PMID: 26055620

4

Prediction of Human Pharmacokinetic Profiles of the Antituberculosis Drug Delamanid from Nonclinical Data: Potential Therapeutic Value against Extrapulmonary Tuberculosis.

Shibata M, Masuda M, Sasahara K, Sasabe H, Sasaki T, Kim S, Takeuchi K, Umehara K, Kashiyama E. Shibata M, et al. Among authors: sasahara k. Antimicrob Agents Chemother. 2021 Jul 16;65(8):e0257120. doi: 10.1128/AAC.02571-20. Epub 2021 Jul 16. Antimicrob Agents Chemother. 2021. PMID: 34097484 Free PMC article.

5

Metabolic Mechanism of Delamanid, a New Anti-Tuberculosis Drug, in Human Plasma.

Shimokawa Y, Sasahara K, Koyama N, Kitano K, Shibata M, Yoda N, Umehara K. Shimokawa Y, et al. Among authors: sasahara k. Drug Metab Dispos. 2015 Aug;43(8):1277-83. doi: 10.1124/dmd.115.064550. Epub 2015 Jun 8. Drug Metab Dispos. 2015. PMID: 26055621

6

Absorption, distribution and excretion of the anti-tuberculosis drug delamanid in rats: Extensive tissue distribution suggests potential therapeutic value for extrapulmonary tuberculosis.

Shibata M, Shimokawa Y, Sasahara K, Yoda N, Sasabe H, Suzuki M, Umehara K. Shibata M, et al. Among authors: sasahara k. Biopharm Drug Dispos. 2017 May;38(4):301-312. doi: 10.1002/bdd.2064. Epub 2017 Mar 8. Biopharm Drug Dispos. 2017. PMID: 28092695

7

Delamanid does not inhibit or induce cytochrome p450 enzymes in vitro.

Shimokawa Y, Sasahara K, Yoda N, Mizuno K, Umehara K. Shimokawa Y, et al. Among authors: sasahara k. Biol Pharm Bull. 2014;37(11):1727-35. doi: 10.1248/bpb.b14-00311. Biol Pharm Bull. 2014. PMID: 25366478 Free article.

8

In vitro evaluations for pharmacokinetic drug-drug interactions of a novel serotonin-dopamine activity modulator, brexpiprazole.

Sasabe H, Koga T, Furukawa M, Matsunaga M, Sasahara K, Hashizume K, Oozone Y, Amunom I, Torii M, Umehara K, Kashiyama E, Takeuchi K. Sasabe H, et al. Among authors: sasahara k. Xenobiotica. 2021 May;51(5):522-535. doi: 10.1080/00498254.2021.1897898. Epub 2021 Mar 11. Xenobiotica. 2021. PMID: 33663326

9

A simple and efficient dispersion correction to the Hartree-Fock theory (3): A comprehensive performance comparison of HF-Dtq with MP2 and DFT-Ds.

Yoshida T, Hayashi T, Mashima A, Sasahara K, Chuman H. Yoshida T, et al. Among authors: sasahara k. Bioorg Med Chem Lett. 2016 Jan 15;26(2):589-593. doi: 10.1016/j.bmcl.2015.11.061. Epub 2015 Nov 29. Bioorg Med Chem Lett. 2016. PMID: 26646216

10

Molecular dynamics and density functional studies on the metabolic selectivity of antipsychotic thioridazine by cytochrome P450 2D6: Connection with crystallographic and metabolic results.

Sasahara K, Mashima A, Yoshida T, Chuman H. Sasahara K, et al. Bioorg Med Chem. 2015 Sep 1;23(17):5459-65. doi: 10.1016/j.bmc.2015.07.043. Epub 2015 Jul 30. Bioorg Med Chem. 2015. PMID: 26264841

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