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Page 1
Discovery of AZD8154, a Dual PI3Kγδ Inhibitor for the Treatment of Asthma.
Perry MWD, Björhall K, Bold P, Brűlls M, Börjesson U, Carlsson J, Chang HA, Chen Y, Eriksson A, Fihn BM, Fransson R, Fredlund L, Ge H, Huang H, Karabelas K, Lamm Bergström E, Lever S, Lindmark H, Mogemark M, Nikitidis A, Palmgren AP, Pemberton N, Petersen J, Rodrigo Blomqvist M, Smith RW, Thomas MJ, Ullah V, Tyrchan C, Wennberg T, Westin Eriksson A, Yang W, Zhao S, Öster L. Perry MWD, et al. Among authors: fredlund l. J Med Chem. 2021 Jun 24;64(12):8053-8075. doi: 10.1021/acs.jmedchem.1c00434. Epub 2021 Jun 3. J Med Chem. 2021. PMID: 34080862
Design and Synthesis of Soluble and Cell-Permeable PI3Kδ Inhibitors for Long-Acting Inhaled Administration.
Perry MWD, Björhall K, Bonn B, Carlsson J, Chen Y, Eriksson A, Fredlund L, Hao H, Holden NS, Karabelas K, Lindmark H, Liu F, Pemberton N, Petersen J, Rodrigo Blomqvist S, Smith RW, Svensson T, Terstiege I, Tyrchan C, Yang W, Zhao S, Öster L. Perry MWD, et al. Among authors: fredlund l. J Med Chem. 2017 Jun 22;60(12):5057-5071. doi: 10.1021/acs.jmedchem.7b00401. Epub 2017 Jun 7. J Med Chem. 2017. PMID: 28520415 Free article.
A Fully Integrated Assay Panel for Early Drug Metabolism and Pharmacokinetics Profiling.
Wernevik J, Bergström F, Novén A, Hulthe J, Fredlund L, Addison D, Holmgren J, Strömstedt PE, Rehnström E, Lundböck T. Wernevik J, et al. Among authors: fredlund l. Assay Drug Dev Technol. 2020 May/Jun;18(4):157-179. doi: 10.1089/adt.2020.970. Epub 2020 May 14. Assay Drug Dev Technol. 2020. PMID: 32407132 Free PMC article.
Rapid PROTAC Discovery Platform: Nanomole-Scale Array Synthesis and Direct Screening of Reaction Mixtures.
Plesniak MP, Taylor EK, Eisele F, Kourra CMBK, Michaelides IN, Oram A, Wernevik J, Valencia ZS, Rowbottom H, Mann N, Fredlund L, Pivnytska V, Novén A, Pirmoradian M, Lundbäck T, Storer RI, Pettersson M, De Donatis GM, Rehnström M. Plesniak MP, et al. Among authors: fredlund l. ACS Med Chem Lett. 2023 Nov 11;14(12):1882-1890. doi: 10.1021/acsmedchemlett.3c00314. eCollection 2023 Dec 14. ACS Med Chem Lett. 2023. PMID: 38116431 Free PMC article.