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Synthesis, Optimization, and Structure-Activity Relationships of Imidazo[1,2-a]pyrimidines as Inhibitors of Group 2 Influenza A Viruses.
Alqarni S, Cooper L, Galvan Achi J, Bott R, Sali VK, Brown A, Santarsiero BD, Krunic A, Manicassamy B, Peet NP, Zhang P, Thatcher GRJ, Gaisina IN, Rong L, Moore TW. Alqarni S, et al. Among authors: gaisina in. J Med Chem. 2022 Oct 27;65(20):14104-14120. doi: 10.1021/acs.jmedchem.2c01329. Epub 2022 Oct 19. J Med Chem. 2022. PMID: 36260129
From a natural product lead to the identification of potent and selective benzofuran-3-yl-(indol-3-yl)maleimides as glycogen synthase kinase 3beta inhibitors that suppress proliferation and survival of pancreatic cancer cells.
Gaisina IN, Gallier F, Ougolkov AV, Kim KH, Kurome T, Guo S, Holzle D, Luchini DN, Blond SY, Billadeau DD, Kozikowski AP. Gaisina IN, et al. J Med Chem. 2009 Apr 9;52(7):1853-63. doi: 10.1021/jm801317h. J Med Chem. 2009. PMID: 19338355 Free PMC article.
40 results