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Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo.
Nat Commun. 2021 May 28;12(1):3210. doi: 10.1038/s41467-021-23561-7.
Nat Commun. 2021.
PMID: 34050192
Free PMC article.
DNA-editing enzymes as potential treatments for heteroplasmic mtDNA diseases.
Zekonyte U, Bacman SR, Moraes CT.
Zekonyte U, et al.
J Intern Med. 2020 Jun;287(6):685-697. doi: 10.1111/joim.13055. Epub 2020 Apr 27.
J Intern Med. 2020.
PMID: 32176378
Free PMC article.
Review.
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mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels.
Pereira CV, Bacman SR, Arguello T, Zekonyte U, Williams SL, Edgell DR, Moraes CT.
Pereira CV, et al. Among authors: zekonyte u.
EMBO Mol Med. 2018 Sep;10(9):e8084. doi: 10.15252/emmm.201708084.
EMBO Mol Med. 2018.
PMID: 30012581
Free PMC article.
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Interlocus gene conversion events introduce deleterious mutations into at least 1% of human genes associated with inherited disease.
Casola C, Zekonyte U, Phillips AD, Cooper DN, Hahn MW.
Casola C, et al. Among authors: zekonyte u.
Genome Res. 2012 Mar;22(3):429-35. doi: 10.1101/gr.127738.111. Epub 2011 Nov 16.
Genome Res. 2012.
PMID: 22090377
Free PMC article.
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