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UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Zheng H, Zhao J, Li B, Zhang W, Stashko MA, Minson KA, Huey MG, Zhou Y, Earp HS, Kireev D, Graham DK, DeRyckere D, Frye SV, Wang X. Zheng H, et al. Among authors: graham dk. Eur J Med Chem. 2021 Aug 5;220:113534. doi: 10.1016/j.ejmech.2021.113534. Epub 2021 May 17. Eur J Med Chem. 2021. PMID: 34038857
Mer receptor tyrosine kinase is a novel therapeutic target in pediatric B-cell acute lymphoblastic leukemia.
Linger RM, DeRyckere D, Brandão L, Sawczyn KK, Jacobsen KM, Liang X, Keating AK, Graham DK. Linger RM, et al. Among authors: graham dk. Blood. 2009 Sep 24;114(13):2678-87. doi: 10.1182/blood-2009-03-209247. Epub 2009 Jul 30. Blood. 2009. Retraction in: Blood. 2012 Aug 16;120(7):1533. doi: 10.1182/blood-2012-06-440792 PMID: 19643988 Free PMC article. Retracted.
Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
Liu J, Yang C, Simpson C, Deryckere D, Van Deusen A, Miley MJ, Kireev D, Norris-Drouin J, Sather S, Hunter D, Korboukh VK, Patel HS, Janzen WP, Machius M, Johnson GL, Earp HS, Graham DK, Frye SV, Wang X. Liu J, et al. Among authors: graham dk. ACS Med Chem Lett. 2012 Feb 9;3(2):129-134. doi: 10.1021/ml200239k. ACS Med Chem Lett. 2012. PMID: 22662287 Free PMC article.
99 results