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UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Zheng H, Zhao J, Li B, Zhang W, Stashko MA, Minson KA, Huey MG, Zhou Y, Earp HS, Kireev D, Graham DK, DeRyckere D, Frye SV, Wang X. Zheng H, et al. Among authors: earp hs. Eur J Med Chem. 2021 Aug 5;220:113534. doi: 10.1016/j.ejmech.2021.113534. Epub 2021 May 17. Eur J Med Chem. 2021. PMID: 34038857
MerTK is required for apoptotic cell-induced T cell tolerance.
Wallet MA, Sen P, Flores RR, Wang Y, Yi Z, Huang Y, Mathews CE, Earp HS, Matsushima G, Wang B, Tisch R. Wallet MA, et al. Among authors: earp hs. J Exp Med. 2008 Jan 21;205(1):219-32. doi: 10.1084/jem.20062293. Epub 2008 Jan 14. J Exp Med. 2008. PMID: 18195070 Free PMC article.
MerTK regulates thymic selection of autoreactive T cells.
Wallet MA, Flores RR, Wang Y, Yi Z, Kroger CJ, Mathews CE, Earp HS, Matsushima G, Wang B, Tisch R. Wallet MA, et al. Among authors: earp hs. Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4810-5. doi: 10.1073/pnas.0900683106. Epub 2009 Feb 27. Proc Natl Acad Sci U S A. 2009. PMID: 19251650 Free PMC article.
221 results