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Page 1
The extracellular matrix protein agrin promotes heart regeneration in mice.
Bassat E, Mutlak YE, Genzelinakh A, Shadrin IY, Baruch Umansky K, Yifa O, Kain D, Rajchman D, Leach J, Riabov Bassat D, Udi Y, Sarig R, Sagi I, Martin JF, Bursac N, Cohen S, Tzahor E. Bassat E, et al. Among authors: tzahor e. Nature. 2017 Jul 13;547(7662):179-184. doi: 10.1038/nature22978. Epub 2017 Jun 5. Nature. 2017. PMID: 28581497 Free PMC article.
Single-cell analysis uncovers that metabolic reprogramming by ErbB2 signaling is essential for cardiomyocyte proliferation in the regenerating heart.
Honkoop H, de Bakker DE, Aharonov A, Kruse F, Shakked A, Nguyen PD, de Heus C, Garric L, Muraro MJ, Shoffner A, Tessadori F, Peterson JC, Noort W, Bertozzi A, Weidinger G, Posthuma G, Grün D, van der Laarse WJ, Klumperman J, Jaspers RT, Poss KD, van Oudenaarden A, Tzahor E, Bakkers J. Honkoop H, et al. Among authors: tzahor e. Elife. 2019 Dec 23;8:e50163. doi: 10.7554/eLife.50163. Elife. 2019. PMID: 31868166 Free PMC article.
ERBB2 drives YAP activation and EMT-like processes during cardiac regeneration.
Aharonov A, Shakked A, Umansky KB, Savidor A, Genzelinakh A, Kain D, Lendengolts D, Revach OY, Morikawa Y, Dong J, Levin Y, Geiger B, Martin JF, Tzahor E. Aharonov A, et al. Among authors: tzahor e. Nat Cell Biol. 2020 Nov;22(11):1346-1356. doi: 10.1038/s41556-020-00588-4. Epub 2020 Oct 12. Nat Cell Biol. 2020. PMID: 33046882
An enhancer-based gene-therapy strategy for spatiotemporal control of cargoes during tissue repair.
Yan R, Cigliola V, Oonk KA, Petrover Z, DeLuca S, Wolfson DW, Vekstein A, Mendiola MA, Devlin G, Bishawi M, Gemberling MP, Sinha T, Sargent MA, York AJ, Shakked A, DeBenedittis P, Wendell DC, Ou J, Kang J, Goldman JA, Baht GS, Karra R, Williams AR, Bowles DE, Asokan A, Tzahor E, Gersbach CA, Molkentin JD, Bursac N, Black BL, Poss KD. Yan R, et al. Among authors: tzahor e. Cell Stem Cell. 2023 Jan 5;30(1):96-111.e6. doi: 10.1016/j.stem.2022.11.012. Epub 2022 Dec 13. Cell Stem Cell. 2023. PMID: 36516837 Free PMC article.
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration.
Nguyen PD, Gooijers I, Campostrini G, Verkerk AO, Honkoop H, Bouwman M, de Bakker DEM, Koopmans T, Vink A, Lamers GEM, Shakked A, Mars J, Mulder AA, Chocron S, Bartscherer K, Tzahor E, Mummery CL, de Boer TP, Bellin M, Bakkers J. Nguyen PD, et al. Among authors: tzahor e. Science. 2023 May 19;380(6646):758-764. doi: 10.1126/science.abo6718. Epub 2023 May 18. Science. 2023. PMID: 37200435
Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury.
Shakked A, Petrover Z, Aharonov A, Ghiringhelli M, Umansky KB, Kain D, Elkahal J, Divinsky Y, Nguyen PD, Miyara S, Friedlander G, Savidor A, Zhang L, Perez DE, Sarig R, Lendengolts D, Bueno-Levy H, Kastan N, Levin Y, Bakkers J, Gepstein L, Tzahor E. Shakked A, et al. Among authors: tzahor e. Nat Cardiovasc Res. 2023 Apr;2(4):383-398. doi: 10.1038/s44161-023-00250-w. Epub 2023 Mar 8. Nat Cardiovasc Res. 2023. PMID: 37974970 Free PMC article.
Egr1 regulates regenerative senescence and cardiac repair.
Zhang L, Elkahal J, Wang T, Rimmer R, Genzelinakh A, Bassat E, Wang J, Perez D, Kain D, Lendengolts D, Winkler R, Bueno-Levy H, Umansky KB, Mishaly D, Shakked A, Miyara S, Sarusi-Portuguez A, Goldfinger N, Prior A, Morgenstern D, Levin Y, Addadi Y, Li B, Rotter V, Katz U, Tanaka EM, Krizhanovsky V, Sarig R, Tzahor E. Zhang L, et al. Among authors: tzahor e. Nat Cardiovasc Res. 2024 Aug;3(8):915-932. doi: 10.1038/s44161-024-00493-1. Epub 2024 Jun 14. Nat Cardiovasc Res. 2024. PMID: 39196027
ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
D'Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, Weisinger K, Bassat E, Rajchman D, Yifa O, Lysenko M, Konfino T, Hegesh J, Brenner O, Neeman M, Yarden Y, Leor J, Sarig R, Harvey RP, Tzahor E. D'Uva G, et al. Among authors: tzahor e. Nat Cell Biol. 2015 May;17(5):627-38. doi: 10.1038/ncb3149. Epub 2015 Apr 6. Nat Cell Biol. 2015. PMID: 25848746
69 results