Stewart AF - Search Results

1

In vivo screen identifies a SIK inhibitor that induces β cell proliferation through a transient UPR.

Charbord J, Ren L, Sharma RB, Johansson A, Ågren R, Chu L, Tworus D, Schulz N, Charbord P, Stewart AF, Wang P, Alonso LC, Andersson O. Charbord J, et al. Among authors: stewart af. Nat Metab. 2021 May;3(5):682-700. doi: 10.1038/s42255-021-00391-x. Epub 2021 May 20. Nat Metab. 2021. PMID: 34031592 Free PMC article.

2

Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice.

Levitt HE, Cyphert TJ, Pascoe JL, Hollern DA, Abraham N, Lundell RJ, Rosa T, Romano LC, Zou B, O'Donnell CP, Stewart AF, Garcia-Ocaña A, Alonso LC. Levitt HE, et al. Among authors: stewart af. Diabetologia. 2011 Mar;54(3):572-82. doi: 10.1007/s00125-010-1919-1. Epub 2010 Oct 9. Diabetologia. 2011. PMID: 20936253 Free PMC article.

3

Disruption of hepatocyte growth factor/c-Met signaling enhances pancreatic beta-cell death and accelerates the onset of diabetes.

Mellado-Gil J, Rosa TC, Demirci C, Gonzalez-Pertusa JA, Velazquez-Garcia S, Ernst S, Valle S, Vasavada RC, Stewart AF, Alonso LC, Garcia-Ocaña A. Mellado-Gil J, et al. Among authors: stewart af. Diabetes. 2011 Feb;60(2):525-36. doi: 10.2337/db09-1305. Epub 2010 Oct 27. Diabetes. 2011. PMID: 20980460 Free PMC article.

4

ChREBP mediates glucose-stimulated pancreatic β-cell proliferation.

Metukuri MR, Zhang P, Basantani MK, Chin C, Stamateris RE, Alonso LC, Takane KK, Gramignoli R, Strom SC, O'Doherty RM, Stewart AF, Vasavada RC, Garcia-Ocaña A, Scott DK. Metukuri MR, et al. Among authors: stewart af. Diabetes. 2012 Aug;61(8):2004-15. doi: 10.2337/db11-0802. Epub 2012 May 14. Diabetes. 2012. PMID: 22586588 Free PMC article.

5

Diabetes mellitus--advances and challenges in human β-cell proliferation.

Wang P, Fiaschi-Taesch NM, Vasavada RC, Scott DK, García-Ocaña A, Stewart AF. Wang P, et al. Among authors: stewart af. Nat Rev Endocrinol. 2015 Apr;11(4):201-12. doi: 10.1038/nrendo.2015.9. Epub 2015 Feb 17. Nat Rev Endocrinol. 2015. PMID: 25687999 Review.

6

A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.

Wang P, Alvarez-Perez JC, Felsenfeld DP, Liu H, Sivendran S, Bender A, Kumar A, Sanchez R, Scott DK, Garcia-Ocaña A, Stewart AF. Wang P, et al. Among authors: stewart af. Nat Med. 2015 Apr;21(4):383-8. doi: 10.1038/nm.3820. Epub 2015 Mar 9. Nat Med. 2015. PMID: 25751815 Free PMC article.

7

Human β-cell proliferation and intracellular signaling: part 3.

Stewart AF, Hussain MA, García-Ocaña A, Vasavada RC, Bhushan A, Bernal-Mizrachi E, Kulkarni RN. Stewart AF, et al. Diabetes. 2015 Jun;64(6):1872-85. doi: 10.2337/db14-1843. Diabetes. 2015. PMID: 25999530 Free PMC article. Review.

8

Augmented Stat5 Signaling Bypasses Multiple Impediments to Lactogen-Mediated Proliferation in Human β-Cells.

Chen H, Kleinberger JW, Takane KK, Salim F, Fiaschi-Taesch N, Pappas K, Parsons R, Jiang J, Zhang Y, Liu H, Wang P, Bender AS, Frank SJ, Stewart AF. Chen H, et al. Among authors: stewart af. Diabetes. 2015 Nov;64(11):3784-97. doi: 10.2337/db15-0083. Epub 2015 Jul 9. Diabetes. 2015. PMID: 26159175 Free PMC article.

9

Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration.

Aamodt KI, Aramandla R, Brown JJ, Fiaschi-Taesch N, Wang P, Stewart AF, Brissova M, Powers AC. Aamodt KI, et al. Among authors: stewart af. Am J Physiol Endocrinol Metab. 2016 Nov 1;311(5):E859-E868. doi: 10.1152/ajpendo.00515.2015. Epub 2016 Sep 13. Am J Physiol Endocrinol Metab. 2016. PMID: 27624103 Free PMC article.

10

Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.

Wang H, Bender A, Wang P, Karakose E, Inabnet WB, Libutti SK, Arnold A, Lambertini L, Stang M, Chen H, Kasai Y, Mahajan M, Kinoshita Y, Fernandez-Ranvier G, Becker TC, Takane KK, Walker LA, Saul S, Chen R, Scott DK, Ferrer J, Antipin Y, Donovan M, Uzilov AV, Reva B, Schadt EE, Losic B, Argmann C, Stewart AF. Wang H, et al. Among authors: stewart af. Nat Commun. 2017 Oct 3;8(1):767. doi: 10.1038/s41467-017-00992-9. Nat Commun. 2017. PMID: 28974674 Free PMC article.

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