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Page 1
Discovery of Icenticaftor (QBW251), a Cystic Fibrosis Transmembrane Conductance Regulator Potentiator with Clinical Efficacy in Cystic Fibrosis and Chronic Obstructive Pulmonary Disease.
Grand DL, Gosling M, Baettig U, Bahra P, Bala K, Brocklehurst C, Budd E, Butler R, Cheung AK, Choudhury H, Collingwood SP, Cox B, Danahay H, Edwards L, Everatt B, Glaenzel U, Glotin AL, Groot-Kormelink P, Hall E, Hatto J, Howsham C, Hughes G, King A, Koehler J, Kulkarni S, Lightfoot M, Nicholls I, Page C, Pergl-Wilson G, Popa MO, Robinson R, Rowlands D, Sharp T, Spendiff M, Stanley E, Steward O, Taylor RJ, Tranter P, Wagner T, Watson H, Williams G, Wright P, Young A, Sandham DA. Grand DL, et al. Among authors: brocklehurst c. J Med Chem. 2021 Jun 10;64(11):7241-7260. doi: 10.1021/acs.jmedchem.1c00343. Epub 2021 May 24. J Med Chem. 2021. PMID: 34028270
Development of autotaxin inhibitors: A series of zinc binding triazoles.
Thomson CG, Le Grand D, Dowling M, Brocklehurst CE, Chinn C, Elphick L, Faller M, Freeman M, Furminger V, Gasser C, Hamadi A, Hardaker E, Head V, Hill JC, Janus DI, Pearce D, Poulaud AS, Stanley E, Sviridenko L. Thomson CG, et al. Among authors: brocklehurst ce. Bioorg Med Chem Lett. 2018 Jul 15;28(13):2279-2284. doi: 10.1016/j.bmcl.2018.05.030. Epub 2018 May 21. Bioorg Med Chem Lett. 2018. PMID: 29798825
MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery.
Brocklehurst CE, Altmann E, Bon C, Davis H, Dunstan D, Ertl P, Ginsburg-Moraff C, Grob J, Gosling DJ, Lapointe G, Marziale AN, Mues H, Palmieri M, Racine S, Robinson RI, Springer C, Tan K, Ulmer W, Wyler R. Brocklehurst CE, et al. J Med Chem. 2024 Feb 8;67(3):2118-2128. doi: 10.1021/acs.jmedchem.3c02029. Epub 2024 Jan 25. J Med Chem. 2024. PMID: 38270627
Correction to "MicroCycle: An Integrated and Automated Platform to Accelerate Drug Discovery".
Brocklehurst CE, Altmann E, André J, Bon C, Caya T, Davis H, Decoret O, Dunstan D, Ertl P, Ginsburg-Moraff C, Grob J, Gosling DJ, Lapointe G, Majumdar D, Marziale AN, Mues H, Palmieri M, Racine S, Robinson RI, Springer C, Tan K, Ulmer W, West L, Wyler R. Brocklehurst CE, et al. J Med Chem. 2024 Mar 28;67(6):5111-5112. doi: 10.1021/acs.jmedchem.4c00452. Epub 2024 Mar 12. J Med Chem. 2024. PMID: 38471144 No abstract available.
Integrated and automated high-throughput purification of libraries on microscale.
Ginsburg-Moraff C, Grob J, Chin K, Eastman G, Wildhaber S, Bayliss M, Mues HM, Palmieri M, Poirier J, Reck M, Luneau A, Rodde S, Reilly J, Wagner T, Brocklehurst CE, Wyler R, Dunstan D, Marziale AN. Ginsburg-Moraff C, et al. Among authors: brocklehurst ce. SLAS Technol. 2022 Dec;27(6):350-360. doi: 10.1016/j.slast.2022.08.002. Epub 2022 Aug 24. SLAS Technol. 2022. PMID: 36028206 Free article.
Building bridges.
Brocklehurst CE, Anderson EA. Brocklehurst CE, et al. Nat Chem. 2021 Oct;13(10):928-930. doi: 10.1038/s41557-021-00784-1. Nat Chem. 2021. PMID: 34584251 No abstract available.
Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.
Sellner H, Chapeau E, Furet P, Voegtle M, Salem B, Le Douget M, Bordas V, Groell JM, Le Goff AL, Rouzet C, Wietlisbach T, Zimmermann T, McKenna J, Brocklehurst CE, Chène P, Wartmann M, Scheufler C, Kallen J, Williams G, Harlfinger S, Traebert M, Dumotier BM, Schmelzle T, Soldermann N. Sellner H, et al. Among authors: brocklehurst ce. ChemMedChem. 2023 Jun 1;18(11):e202300051. doi: 10.1002/cmdc.202300051. Epub 2023 Apr 13. ChemMedChem. 2023. PMID: 36988034
Small-molecule WNK inhibition regulates cardiovascular and renal function.
Yamada K, Park HM, Rigel DF, DiPetrillo K, Whalen EJ, Anisowicz A, Beil M, Berstler J, Brocklehurst CE, Burdick DA, Caplan SL, Capparelli MP, Chen G, Chen W, Dale B, Deng L, Fu F, Hamamatsu N, Harasaki K, Herr T, Hoffmann P, Hu QY, Huang WJ, Idamakanti N, Imase H, Iwaki Y, Jain M, Jeyaseelan J, Kato M, Kaushik VK, Kohls D, Kunjathoor V, LaSala D, Lee J, Liu J, Luo Y, Ma F, Mo R, Mowbray S, Mogi M, Ossola F, Pandey P, Patel SJ, Raghavan S, Salem B, Shanado YH, Trakshel GM, Turner G, Wakai H, Wang C, Weldon S, Wielicki JB, Xie X, Xu L, Yagi YI, Yasoshima K, Yin J, Yowe D, Zhang JH, Zheng G, Monovich L. Yamada K, et al. Among authors: brocklehurst ce. Nat Chem Biol. 2016 Nov;12(11):896-898. doi: 10.1038/nchembio.2168. Epub 2016 Sep 5. Nat Chem Biol. 2016. PMID: 27595330
35 results