Kogame A - Search Results

1

A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery.

Iwai K, Nambu T, Kashima Y, Yu J, Eng K, Miyamoto K, Kakoi K, Gotou M, Takeuchi T, Kogame A, Sappal J, Murai S, Haeno H, Kageyama SI, Kurasawa O, Niu H, Kannan K, Ohashi A. Iwai K, et al. Among authors: kogame a. Sci Adv. 2021 May 21;7(21):eabf0197. doi: 10.1126/sciadv.abf0197. Print 2021 May. Sci Adv. 2021. PMID: 34020950 Free PMC article.

2

Pharmacokinetic and pharmacodynamic modeling of the metastin/kisspeptin analog, TAK-448, for its anti-tumor efficacy in a rat xenograft model.

Kogame A, Ishikawa K, DeJongh J, Tagawa Y, Matsui H, Moriya Y, Kondo T, Asahi S. Kogame A, et al. Biopharm Drug Dispos. 2020 Jul;41(7):283-294. doi: 10.1002/bdd.2245. Epub 2020 Jul 16. Biopharm Drug Dispos. 2020. PMID: 32562504

3

The Enhancement of Subcutaneous First-Pass Metabolism Causes Nonlinear Pharmacokinetics of TAK-448 after a Single Subcutaneous Administration to Rats.

Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ. Moriya Y, et al. Among authors: kogame a. Drug Metab Dispos. 2019 Sep;47(9):1004-1012. doi: 10.1124/dmd.119.087148. Epub 2019 Jun 14. Drug Metab Dispos. 2019. PMID: 31201213

4

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor.

Iwai K, Nambu T, Dairiki R, Ohori M, Yu J, Burke K, Gotou M, Yamamoto Y, Ebara S, Shibata S, Hibino R, Nishizawa S, Miyazaki T, Homma M, Oguro Y, Imada T, Cho N, Uchiyama N, Kogame A, Takeuchi T, Kurasawa O, Yamanaka K, Niu H, Ohashi A. Iwai K, et al. Among authors: kogame a. Sci Adv. 2019 May 22;5(5):eaav3660. doi: 10.1126/sciadv.aav3660. eCollection 2019 May. Sci Adv. 2019. PMID: 31131319 Free PMC article.

5

Characterization of Fasiglifam-Related Liver Toxicity in Dogs.

Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ. Kogame A, et al. Drug Metab Dispos. 2019 May;47(5):525-534. doi: 10.1124/dmd.118.084889. Epub 2019 Feb 14. Drug Metab Dispos. 2019. PMID: 30765394

6

Investigation of disposition for TAK-448, a synthetic peptide of kisspeptin analog, in rats and dogs using the radiolabeled TAK-448 suitable for pharmacokinetic study.

Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S. Moriya Y, et al. Among authors: kogame a. Xenobiotica. 2019 Jul;49(7):833-839. doi: 10.1080/00498254.2018.1499152. Epub 2018 Sep 12. Xenobiotica. 2019. PMID: 30044673

7

Usefulness of pharmacokinetic/efficacy analysis of an investigational kisspeptin analog, TAK-448, in quantitatively evaluating anti-tumor growth effect in the rat VCaP androgen-sensitive prostate cancer model.

Ishikawa K, Tanaka A, Kogame A, Watanabe T, Tagawa Y, Matsui H. Ishikawa K, et al. Among authors: kogame a. Eur J Pharmacol. 2018 Jun 5;828:126-134. doi: 10.1016/j.ejphar.2018.03.032. Epub 2018 Mar 23. Eur J Pharmacol. 2018. PMID: 29580912

8

Disposition and metabolism of the G protein-coupled receptor 40 agonist TAK-875 (fasiglifam) in rats, dogs, and humans.

Kogame A, Lee R, Pan L, Sudo M, Nonaka M, Moriya Y, Higuchi T, Tagawa Y. Kogame A, et al. Xenobiotica. 2019 Apr;49(4):433-445. doi: 10.1080/00498254.2018.1453100. Epub 2018 Apr 5. Xenobiotica. 2019. PMID: 29557709 Clinical Trial.

9

Evaluation of the Pharmacokinetics and Safety of a Single Oral Dose of Fasiglifam in Subjects with Mild or Moderate Hepatic Impairment.

Marcinak J, Vakilynejad M, Kogame A, Tagawa Y. Marcinak J, et al. Among authors: kogame a. Drugs R D. 2018 Jun;18(2):109-118. doi: 10.1007/s40268-018-0229-9. Drugs R D. 2018. PMID: 29488154 Free PMC article. Clinical Trial.

10

Influence of the pharmacokinetic profile on the plasma glucose lowering effect of the PPARγ agonist pioglitazone in Wistar fatty rats.

Goto A, Tagawa Y, Kimura Y, Kogame A, Moriya Y, Amano N. Goto A, et al. Among authors: kogame a. Biopharm Drug Dispos. 2017 Sep;38(6):381-388. doi: 10.1002/bdd.2076. Epub 2017 May 28. Biopharm Drug Dispos. 2017. PMID: 28294376

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