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A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery.
Iwai K, Nambu T, Kashima Y, Yu J, Eng K, Miyamoto K, Kakoi K, Gotou M, Takeuchi T, Kogame A, Sappal J, Murai S, Haeno H, Kageyama SI, Kurasawa O, Niu H, Kannan K, Ohashi A. Iwai K, et al. Among authors: kageyama si. Sci Adv. 2021 May 21;7(21):eabf0197. doi: 10.1126/sciadv.abf0197. Print 2021 May. Sci Adv. 2021. PMID: 34020950 Free PMC article.
Impacts of the STING-IFNAR1-STAT1-IRF1 pathway on the cellular immune reaction induced by fractionated irradiation.
Du J, Kageyama SI, Yamashita R, Hirata H, Hakozaki Y, Okumura M, Motegi A, Hojo H, Nakamura M, Hirano Y, Sunakawa H, Minamide T, Kotani D, Tanaka K, Yano T, Kojima T, Ohashi A, Tsuchihara K, Akimoto T. Du J, et al. Among authors: kageyama si. Cancer Sci. 2022 Apr;113(4):1352-1361. doi: 10.1111/cas.15297. Epub 2022 Feb 20. Cancer Sci. 2022. PMID: 35133062 Free PMC article.
CDC7 inhibition induces replication stress-mediated aneuploid cells with an inflammatory phenotype sensitizing tumors to immune checkpoint blockade.
Morita TY, Yu J, Kashima Y, Kamata R, Yamamoto G, Minamide T, Mashima C, Yoshiya M, Sakae Y, Yamauchi T, Hakozaki Y, Kageyama SI, Nakamura A, Lightcap E, Tanaka K, Niu H, Kannan K, Ohashi A. Morita TY, et al. Among authors: kageyama si. Nat Commun. 2023 Nov 18;14(1):7490. doi: 10.1038/s41467-023-43274-3. Nat Commun. 2023. PMID: 37980406 Free PMC article.
Mathematical modeling predicts optimal immune checkpoint inhibitor and radiotherapy combinations and timing of administration.
Sakai SA, Saeki K, Chi S, Hamaya Y, Du J, Nakamura M, Hojo H, Kojima T, Nakamura Y, Bando H, Kojima M, Suzuki A, Suzuki Y, Akimoto T, Tsuchihara K, Haeno H, Yamashita R, Kageyama SI. Sakai SA, et al. Among authors: kageyama si. Cancer Immunol Res. 2024 Dec 12. doi: 10.1158/2326-6066.CIR-24-0610. Online ahead of print. Cancer Immunol Res. 2024. PMID: 39666379
Comprehensive single-cell analysis demonstrates radiotherapy-induced infiltration of macrophages expressing immunosuppressive genes into tumor in esophageal squamous cell carcinoma.
Oyoshi H, Du J, Sakai SA, Yamashita R, Okumura M, Motegi A, Hojo H, Nakamura M, Hirata H, Sunakawa H, Kotani D, Yano T, Kojima T, Nakamura Y, Kojima M, Suzuki A, Zenkoh J, Tsuchihara K, Akimoto T, Shibata A, Suzuki Y, Kageyama SI. Oyoshi H, et al. Among authors: kageyama si. Sci Adv. 2023 Dec 15;9(50):eadh9069. doi: 10.1126/sciadv.adh9069. Epub 2023 Dec 13. Sci Adv. 2023. PMID: 38091397 Free PMC article.
Comprehensive screening for drugs that modify radiation-induced immune responses.
Okumura M, Du J, Kageyama SI, Yamashita R, Hakozaki Y, Motegi A, Hojo H, Nakamura M, Hirano Y, Okuma Y, Okuma HS, Tsuchihara K, Akimoto T. Okumura M, et al. Among authors: kageyama si. Br J Cancer. 2022 Jun;126(12):1815-1823. doi: 10.1038/s41416-021-01688-0. Epub 2022 Feb 19. Br J Cancer. 2022. PMID: 35184156 Free PMC article.
Transposable elements potentiate radiotherapy-induced cellular immune reactions via RIG-I-mediated virus-sensing pathways.
Du J, Kageyama SI, Yamashita R, Tanaka K, Okumura M, Motegi A, Hojo H, Nakamura M, Hirata H, Sunakawa H, Kotani D, Yano T, Kojima T, Hamaya Y, Kojima M, Nakamura Y, Suzuki A, Suzuki Y, Tsuchihara K, Akimoto T. Du J, et al. Among authors: kageyama si. Commun Biol. 2023 Aug 5;6(1):818. doi: 10.1038/s42003-023-05080-x. Commun Biol. 2023. PMID: 37543704 Free PMC article.
64 results