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Functionally distinct POMC-expressing neuron subpopulations in hypothalamus revealed by intersectional targeting.
Biglari N, Gaziano I, Schumacher J, Radermacher J, Paeger L, Klemm P, Chen W, Corneliussen S, Wunderlich CM, Sue M, Vollmar S, Klöckener T, Sotelo-Hitschfeld T, Abbasloo A, Edenhofer F, Reimann F, Gribble FM, Fenselau H, Kloppenburg P, Wunderlich FT, Brüning JC. Biglari N, et al. Among authors: chen w. Nat Neurosci. 2021 Jul;24(7):913-929. doi: 10.1038/s41593-021-00854-0. Epub 2021 May 17. Nat Neurosci. 2021. PMID: 34002087 Free PMC article.
HypoMap-a unified single-cell gene expression atlas of the murine hypothalamus.
Steuernagel L, Lam BYH, Klemm P, Dowsett GKC, Bauder CA, Tadross JA, Hitschfeld TS, Del Rio Martin A, Chen W, de Solis AJ, Fenselau H, Davidsen P, Cimino I, Kohnke SN, Rimmington D, Coll AP, Beyer A, Yeo GSH, Brüning JC. Steuernagel L, et al. Among authors: chen w. Nat Metab. 2022 Oct;4(10):1402-1419. doi: 10.1038/s42255-022-00657-y. Epub 2022 Oct 20. Nat Metab. 2022. PMID: 36266547 Free PMC article.
Circulating uridine dynamically and adaptively regulates food intake in humans.
Hanssen R, Rigoux L, Albus K, Kretschmer AC, Edwin Thanarajah S, Chen W, Hinze Y, Giavalisco P, Steculorum SM, Cornely OA, Brüning JC, Tittgemeyer M. Hanssen R, et al. Among authors: chen w. Cell Rep Med. 2023 Jan 17;4(1):100897. doi: 10.1016/j.xcrm.2022.100897. Cell Rep Med. 2023. PMID: 36652907 Free PMC article.
Nutrient-sensing AgRP neurons relay control of liver autophagy during energy deprivation.
Chen W, Mehlkop O, Scharn A, Nolte H, Klemm P, Henschke S, Steuernagel L, Sotelo-Hitschfeld T, Kaya E, Wunderlich CM, Langer T, Kononenko NL, Giavalisco P, Brüning JC. Chen W, et al. Cell Metab. 2023 May 2;35(5):786-806.e13. doi: 10.1016/j.cmet.2023.03.019. Epub 2023 Apr 18. Cell Metab. 2023. PMID: 37075752 Free PMC article.
Reciprocal activity of AgRP and POMC neurons governs coordinated control of feeding and metabolism.
De Solis AJ, Del Río-Martín A, Radermacher J, Chen W, Steuernagel L, Bauder CA, Eggersmann FR, Morgan DA, Cremer AL, Sué M, Germer M, Kukat C, Vollmar S, Backes H, Rahmouni K, Kloppenburg P, Brüning JC. De Solis AJ, et al. Among authors: chen w. Nat Metab. 2024 Mar;6(3):473-493. doi: 10.1038/s42255-024-00987-z. Epub 2024 Feb 20. Nat Metab. 2024. PMID: 38378998 Free PMC article.
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