May LT - Search Results

1

Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus.

Roberts MJ, May LT, Keen AC, Liu B, Lam T, Charlton SJ, Rosethorne EM, Halls ML. Roberts MJ, et al. Among authors: may lt. Front Pharmacol. 2021 Apr 29;12:669227. doi: 10.3389/fphar.2021.669227. eCollection 2021. Front Pharmacol. 2021. PMID: 33995100 Free PMC article.

2

Targeting Adenosine Receptors for the Treatment of Cardiac Fibrosis.

Vecchio EA, White PJ, May LT. Vecchio EA, et al. Among authors: may lt. Front Pharmacol. 2017 May 5;8:243. doi: 10.3389/fphar.2017.00243. eCollection 2017. Front Pharmacol. 2017. PMID: 28529484 Free PMC article. Review.

3

Development and Application of Subtype-Selective Fluorescent Antagonists for the Study of the Human Adenosine A₁ Receptor in Living Cells.

Comeo E, Trinh P, Nguyen AT, Nowell CJ, Kindon ND, Soave M, Stoddart LA, White JM, Hill SJ, Kellam B, Halls ML, May LT, Scammells PJ. Comeo E, et al. Among authors: may lt. J Med Chem. 2021 May 27;64(10):6670-6695. doi: 10.1021/acs.jmedchem.0c02067. Epub 2021 Mar 16. J Med Chem. 2021. PMID: 33724031 Free article.

4

Pharmacological Insights Into Safety and Efficacy Determinants for the Development of Adenosine Receptor Biased Agonists in the Treatment of Heart Failure.

Rueda P, Merlin J, Chimenti S, Feletou M, Paysant J, White PJ, Christopoulos A, Sexton PM, Summers RJ, Charman WN, May LT, Langmead CJ. Rueda P, et al. Among authors: may lt. Front Pharmacol. 2021 Mar 11;12:628060. doi: 10.3389/fphar.2021.628060. eCollection 2021. Front Pharmacol. 2021. PMID: 33776771 Free PMC article.

5

The application of artificial intelligence to accelerate G protein-coupled receptor drug discovery.

Nguyen ATN, Nguyen DTN, Koh HY, Toskov J, MacLean W, Xu A, Zhang D, Webb GI, May LT, Halls ML. Nguyen ATN, et al. Among authors: may lt. Br J Pharmacol. 2024 Jul;181(14):2371-2384. doi: 10.1111/bph.16140. Epub 2023 May 26. Br J Pharmacol. 2024. PMID: 37161878 Review.

6

Biased receptor signalling and intracellular trafficking profiles of structurally distinct formylpeptide receptor 2 agonists.

Peng C, Vecchio EA, Nguyen ATN, De Seram M, Tang R, Keov P, Woodman OL, Chen YC, Baell J, May LT, Zhao P, Ritchie RH, Qin CX. Peng C, et al. Among authors: may lt. Br J Pharmacol. 2024 Nov;181(22):4677-4692. doi: 10.1111/bph.17310. Epub 2024 Aug 18. Br J Pharmacol. 2024. PMID: 39154373

7

The effect of allosteric modulators on the kinetics of agonist-G protein-coupled receptor interactions in single living cells.

May LT, Self TJ, Briddon SJ, Hill SJ. May LT, et al. Mol Pharmacol. 2010 Sep;78(3):511-23. doi: 10.1124/mol.110.064493. Epub 2010 Jun 22. Mol Pharmacol. 2010. PMID: 20571079 Free PMC article.

8

Insights into GPCR pharmacology from the measurement of changes in intracellular cyclic AMP; advantages and pitfalls of differing methodologies.

Hill SJ, Williams C, May LT. Hill SJ, et al. Among authors: may lt. Br J Pharmacol. 2010 Nov;161(6):1266-75. doi: 10.1111/j.1476-5381.2010.00779.x. Br J Pharmacol. 2010. PMID: 21049583 Free PMC article. Review.

9

Allosteric modulation of endogenous metabolites as an avenue for drug discovery.

Wootten D, Savage EE, Valant C, May LT, Sloop KW, Ficorilli J, Showalter AD, Willard FS, Christopoulos A, Sexton PM. Wootten D, et al. Among authors: may lt. Mol Pharmacol. 2012 Aug;82(2):281-90. doi: 10.1124/mol.112.079319. Epub 2012 May 10. Mol Pharmacol. 2012. PMID: 22576254

10

Allosteric interactions at adenosine A(1) and A(3) receptors: new insights into the role of small molecules and receptor dimerization.

Hill SJ, May LT, Kellam B, Woolard J. Hill SJ, et al. Among authors: may lt. Br J Pharmacol. 2014 Mar;171(5):1102-13. doi: 10.1111/bph.12345. Br J Pharmacol. 2014. PMID: 24024783 Free PMC article. Review.

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