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Deep learning for diagnosis of acute promyelocytic leukemia via recognition of genomically imprinted morphologic features.
Sidhom JW, Siddarthan IJ, Lai BS, Luo A, Hambley BC, Bynum J, Duffield AS, Streiff MB, Moliterno AR, Imus P, Gocke CB, Gondek LP, DeZern AE, Baras AS, Kickler T, Levis MJ, Shenderov E. Sidhom JW, et al. Among authors: gondek lp. NPJ Precis Oncol. 2021 May 14;5(1):38. doi: 10.1038/s41698-021-00179-y. NPJ Precis Oncol. 2021. PMID: 33990660 Free PMC article.
Integration of Hedgehog and mutant FLT3 signaling in myeloid leukemia.
Lim Y, Gondek L, Li L, Wang Q, Ma H, Chang E, Huso DL, Foerster S, Marchionni L, McGovern K, Watkins DN, Peacock CD, Levis M, Smith BD, Merchant AA, Small D, Matsui W. Lim Y, et al. Sci Transl Med. 2015 Jun 10;7(291):291ra96. doi: 10.1126/scitranslmed.aaa5731. Sci Transl Med. 2015. PMID: 26062848 Free PMC article.
Hedgehog/GLI1 activation leads to leukemic transformation of myelodysplastic syndrome in vivo and GLI1 inhibition results in antitumor activity.
Lau BW, Huh K, Madero-Marroquin R, De Marchi F, Lim Y, Wang Q, Lobo F, Marchionni L, Smith DB, DeZern A, Levis MJ, Aplan PD, Matsui W, Gondek LP. Lau BW, et al. Among authors: gondek lp. Oncogene. 2019 Jan;38(5):687-698. doi: 10.1038/s41388-018-0431-9. Epub 2018 Aug 31. Oncogene. 2019. PMID: 30171262 Free PMC article.
Fibrinogen consumption and use of heparin are risk factors for delayed bleeding during acute promyelocytic leukemia induction.
Hambley BC, Norsworthy KJ, Jasem J, Zimmerman JW, Shenderov E, Webster JA, Showel MM, Gondek LP, Dalton WB, Prince G, Gladstone DE, Streiff MB, Pratz KW, Gojo I, Ghiaur G, Levis MJ, Smith BD, DeZern AE. Hambley BC, et al. Among authors: gondek lp. Leuk Res. 2019 Aug;83:106174. doi: 10.1016/j.leukres.2019.106174. Epub 2019 Jun 21. Leuk Res. 2019. PMID: 31255938 Clinical Trial. No abstract available.
Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation.
Dalton WB, Helmenstine E, Walsh N, Gondek LP, Kelkar DS, Read A, Natrajan R, Christenson ES, Roman B, Das S, Zhao L, Leone RD, Shinn D, Groginski T, Madugundu AK, Patil A, Zabransky DJ, Medford A, Lee J, Cole AJ, Rosen M, Thakar M, Ambinder A, Donaldson J, DeZern AE, Cravero K, Chu D, Madero-Marroquin R, Pandey A, Hurley PJ, Lauring J, Park BH. Dalton WB, et al. Among authors: gondek lp. J Clin Invest. 2019 Aug 8;129(11):4708-4723. doi: 10.1172/JCI125022. J Clin Invest. 2019. PMID: 31393856 Free PMC article.
75 results