Ropa J - Search Results

1

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.

Rogawski DS, Deng J, Li H, Miao H, Borkin D, Purohit T, Song J, Chase J, Li S, Ndoj J, Klossowski S, Kim E, Mao F, Zhou B, Ropa J, Krotoska MZ, Jin Z, Ernst P, Feng X, Huang G, Nishioka K, Kelly S, He M, Wen B, Sun D, Muntean A, Dou Y, Maillard I, Cierpicki T, Grembecka J. Rogawski DS, et al. Among authors: ropa j. Nat Commun. 2021 May 14;12(1):2792. doi: 10.1038/s41467-021-23152-6. Nat Commun. 2021. PMID: 33990599 Free PMC article.

2

Mutated Ptpn11 alters leukemic stem cell frequency and reduces the sensitivity of acute myeloid leukemia cells to Mcl1 inhibition.

Chen L, Chen W, Mysliwski M, Serio J, Ropa J, Abulwerdi FA, Chan RJ, Patel JP, Tallman MS, Paietta E, Melnick A, Levine RL, Abdel-Wahab O, Nikolovska-Coleska Z, Muntean AG. Chen L, et al. Among authors: ropa j. Leukemia. 2015 Jun;29(6):1290-300. doi: 10.1038/leu.2015.18. Epub 2015 Feb 4. Leukemia. 2015. PMID: 25650089 Free PMC article.

3

The PAF complex regulation of Prmt5 facilitates the progression and maintenance of MLL fusion leukemia.

Serio J, Ropa J, Chen W, Mysliwski M, Saha N, Chen L, Wang J, Miao H, Cierpicki T, Grembecka J, Muntean AG. Serio J, et al. Among authors: ropa j. Oncogene. 2018 Jan 25;37(4):450-460. doi: 10.1038/onc.2017.337. Epub 2017 Sep 25. Oncogene. 2018. PMID: 28945229 Free PMC article.

4

PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia.

Ropa J, Saha N, Chen Z, Serio J, Chen W, Mellacheruvu D, Zhao L, Basrur V, Nesvizhskii AI, Muntean AG. Ropa J, et al. Oncotarget. 2018 Apr 24;9(31):22123-22136. doi: 10.18632/oncotarget.25204. eCollection 2018 Apr 24. Oncotarget. 2018. PMID: 29774127 Free PMC article.

5

p38-mediated phosphorylation at T367 induces EZH2 cytoplasmic localization to promote breast cancer metastasis.

Anwar T, Arellano-Garcia C, Ropa J, Chen YC, Kim HS, Yoon E, Grigsby S, Basrur V, Nesvizhskii AI, Muntean A, Gonzalez ME, Kidwell KM, Nikolovska-Coleska Z, Kleer CG. Anwar T, et al. Among authors: ropa j. Nat Commun. 2018 Jul 18;9(1):2801. doi: 10.1038/s41467-018-05078-8. Nat Commun. 2018. PMID: 30022044 Free PMC article.

6

The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation.

Saha N, Ropa J, Chen L, Hu H, Mysliwski M, Friedman A, Maillard I, Muntean AG. Saha N, et al. Among authors: ropa j. Stem Cell Reports. 2019 May 14;12(5):1069-1083. doi: 10.1016/j.stemcr.2019.03.010. Epub 2019 Apr 25. Stem Cell Reports. 2019. PMID: 31031188 Free PMC article.

7

[No title available]

[No authors listed] [No authors listed] PMID: 31558673

8

[No title available]

[No authors listed] [No authors listed] PMID: 33024997

9

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation.

Ropa J, Saha N, Hu H, Peterson LF, Talpaz M, Muntean AG. Ropa J, et al. Haematologica. 2020 Sep 1;105(9):2273-2285. doi: 10.3324/haematol.2019.223883. Haematologica. 2020. PMID: 33054052 Free PMC article.

10

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations.

Miao H, Kim E, Chen D, Purohit T, Kempinska K, Ropa J, Klossowski S, Trotman W, Danet-Desnoyers G, Cierpicki T, Grembecka J. Miao H, et al. Among authors: ropa j. Blood. 2020 Dec 17;136(25):2958-2963. doi: 10.1182/blood.2020006575. Blood. 2020. PMID: 33331926 Free PMC article. Clinical Trial. No abstract available.

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