Polacek N - Search Results

1

Context-specific action of macrolide antibiotics on the eukaryotic ribosome.

Svetlov MS, Koller TO, Meydan S, Shankar V, Klepacki D, Polacek N, Guydosh NR, Vázquez-Laslop N, Wilson DN, Mankin AS. Svetlov MS, et al. Among authors: polacek n. Nat Commun. 2021 May 14;12(1):2803. doi: 10.1038/s41467-021-23068-1. Nat Commun. 2021. PMID: 33990576 Free PMC article.

2

Ribosomal peptidyl transferase can withstand mutations at the putative catalytic nucleotide.

Polacek N, Gaynor M, Yassin A, Mankin AS. Polacek N, et al. Nature. 2001 May 24;411(6836):498-501. doi: 10.1038/35078113. Nature. 2001. PMID: 11373685

3

pKa of adenine 2451 in the ribosomal peptidyl transferase center remains elusive.

Xiong L, Polacek N, Sander P, Böttger EC, Mankin A. Xiong L, et al. Among authors: polacek n. RNA. 2001 Oct;7(10):1365-9. RNA. 2001. PMID: 11680840 Free PMC article.

4

SPARK--a novel method to monitor ribosomal peptidyl transferase activity.

Polacek N, Swaney S, Shinabarger D, Mankin AS. Polacek N, et al. Biochemistry. 2002 Oct 1;41(39):11602-10. doi: 10.1021/bi026040s. Biochemistry. 2002. PMID: 12269803

5

The critical role of the universally conserved A2602 of 23S ribosomal RNA in the release of the nascent peptide during translation termination.

Polacek N, Gomez MJ, Ito K, Xiong L, Nakamura Y, Mankin A. Polacek N, et al. Mol Cell. 2003 Jan;11(1):103-12. doi: 10.1016/s1097-2765(02)00825-0. Mol Cell. 2003. PMID: 12535525 Free article.

6

Chemical engineering of the peptidyl transferase center reveals an important role of the 2'-hydroxyl group of A2451.

Erlacher MD, Lang K, Shankaran N, Wotzel B, Hüttenhofer A, Micura R, Mankin AS, Polacek N. Erlacher MD, et al. Among authors: polacek n. Nucleic Acids Res. 2005 Mar 14;33(5):1618-27. doi: 10.1093/nar/gki308. Print 2005. Nucleic Acids Res. 2005. PMID: 15767286 Free PMC article.

7

The ribosomal peptidyl transferase center: structure, function, evolution, inhibition.

Polacek N, Mankin AS. Polacek N, et al. Crit Rev Biochem Mol Biol. 2005 Sep-Oct;40(5):285-311. doi: 10.1080/10409230500326334. Crit Rev Biochem Mol Biol. 2005. PMID: 16257828 Review.

8

The highly conserved LepA is a ribosomal elongation factor that back-translocates the ribosome.

Qin Y, Polacek N, Vesper O, Staub E, Einfeldt E, Wilson DN, Nierhaus KH. Qin Y, et al. Among authors: polacek n. Cell. 2006 Nov 17;127(4):721-33. doi: 10.1016/j.cell.2006.09.037. Cell. 2006. PMID: 17110332 Free article.

9

SPARK: a new peptidyl transferase activity assay.

Mankin AS, Polacek N. Mankin AS, et al. Among authors: polacek n. Methods Mol Med. 2008;142:107-16. doi: 10.1007/978-1-59745-246-5_9. Methods Mol Med. 2008. PMID: 18437309

10

The role of 23S ribosomal RNA residue A2451 in peptide bond synthesis revealed by atomic mutagenesis.

Lang K, Erlacher M, Wilson DN, Micura R, Polacek N. Lang K, et al. Among authors: polacek n. Chem Biol. 2008 May;15(5):485-92. doi: 10.1016/j.chembiol.2008.03.014. Epub 2008 Apr 24. Chem Biol. 2008. PMID: 18439847

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