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Whole-genome doubling confers unique genetic vulnerabilities on tumour cells.
Quinton RJ, DiDomizio A, Vittoria MA, Kotýnková K, Ticas CJ, Patel S, Koga Y, Vakhshoorzadeh J, Hermance N, Kuroda TS, Parulekar N, Taylor AM, Manning AL, Campbell JD, Ganem NJ. Quinton RJ, et al. Among authors: kotynkova k. Nature. 2021 Feb;590(7846):492-497. doi: 10.1038/s41586-020-03133-3. Epub 2021 Jan 27. Nature. 2021. PMID: 33505027 Free PMC article.
Inactivation of the Hippo tumor suppressor pathway promotes melanoma.
Vittoria MA, Kingston N, Kotynkova K, Xia E, Hong R, Huang L, McDonald S, Tilston-Lunel A, Darp R, Campbell JD, Lang D, Xu X, Ceol CJ, Varelas X, Ganem NJ. Vittoria MA, et al. Among authors: kotynkova k. Nat Commun. 2022 Jun 29;13(1):3732. doi: 10.1038/s41467-022-31399-w. Nat Commun. 2022. PMID: 35768444 Free PMC article.
Velcrin molecular glues induce apoptosis in glioblastomas with high PDE3A and SLFN12 expression.
Aquilanti E, Goldoni S, Baker A, Kotynkova K, Andersen S, Bozinov V, Gao GF, Cherniack AD, Lange M, Lesche R, Kopitz C, Lienau P, Lewis TA, Garrido M, Gradl S, Seidel H, Tseng YY, Ligon KL, Wen PY, Meyerson M, Greulich H. Aquilanti E, et al. Among authors: kotynkova k. Neurooncol Adv. 2024 Jul 1;6(1):vdae115. doi: 10.1093/noajnl/vdae115. eCollection 2024 Jan-Dec. Neurooncol Adv. 2024. PMID: 39166256 Free PMC article.